Pharm Ingredients
Betaine Anhydrous Powder
What Is Betaine Anhydrous Powder?
As a leading global manufacturer of plant extracts and pharmaceutical intermediates, Kintainutri® is dedicated to supplying high-quality anhydrous betaine powder in large volumes to customers worldwide. We utilize proven, standardized chemical synthesis processes to ensure consistent quality and an assayed purity of over 98%–99%.
| Product Name | Source | Best-selling Specifications |
|---|---|---|
| Betaine Anhydrous Powder | Synthesis | 98%-99% |
| Sugar Beet Roots |
Our product holds multiple internationally recognized certifications, including GMP, ISO 22000, HALAL, and KOSHER, and complies with applicable EU food safety regulations and EFSA requirements. Whether for pharmaceutical intermediates, premium cosmetic moisturizers, dietary supplements, or additives for animal nutrition and aquaculture feed, Kintainutri® is ready to meet your needs with ample inventory and flexible, customized solutions.
Betaine Anhydrous Powder Specification
| Analysis | Specification | Test Method | |
|---|---|---|---|
| Physical and Chemical Property | |||
| Appearance | white, free-flowing crystals | Visual | |
| Odour, taste | pure, specific with faint molasses odour | Smell | |
| Particle size | ≥95% through 80 mesh | Screening | |
| Residue on Ignition | ≤1g/100g | 3g/550°C/4hrs | |
| Loss on Drying | ≤5g/100g | 3g/105°C/2hrs | |
| Identification | Conforms with TLC | TLC | |
| Content | 99% Betaine content | HPLC | |
| Residue Analysis | |||
| Heavy Metals | ≤10mg/kg | ||
| Lead (Pb) | ≤1.00mg/kg | ICP-MS | |
| Arsenic (As) | ≤1.00mg/kg | ICP-MS | |
| Cadmium (Cd) | ≤1.00mg/kg | ICP-MS | |
| Mercury (Hg) | ≤0.50mg/kg | ICP-MS | |
| Microbiological Tests | |||
| Total Plate Count | ≤100cfu/g | AOAC 990.12 | |
| Total Yeast & Mold | ≤100cfu/g | AOAC 997.02 | |
| E.Coli | Negative/10g | AOAC 991.14 | |
| Salmonella | Negative/10g | AOAC 998.09 | |
| S.aureus | Negative/10g | AOAC 2003.07 | |
How To Make Betaine Anhydrous Powder?
Betaine Anhydrous Powder Benefits
Betaine anhydrous blood pressure
Betaine powder significantly elevates serum nitric oxide (NO) levels and improves vascular endothelial function by promoting homocysteine remethylation; simultaneously, it significantly reduces the expression of angiotensin-converting enzyme (ACE), thereby inhibiting the overactivation of the renin-angiotensin system. Furthermore, the renal oxidative stress marker TBARS is significantly reduced, indicating an improvement in systemic oxidative stress status.
These findings suggest that our anhydrous betaine can serve as an active ingredient in functional foods and dietary supplements for cardiovascular health, making it particularly suitable for blood pressure management in populations at risk of hypertension.
Betaine anhydrous for bodybuilding
Continuous supplementation with anhydrous betaine (2.5 g/day) combined with resistance training can significantly improve body composition by reducing body fat percentage and increasing lean body mass, while also increasing arm circumference and enhancing training volume, particularly during phases of high metabolic demand. Betaine supports exercise performance and muscle protein synthesis during high-intensity training by maintaining cellular hydration, preserving myosin ATPase activity, and improving insulin signaling pathways.
It also indirectly influences muscle mass through its role as an organic osmolyte. As a result, betaine anhydrous for muscle growth has become a valuable ingredient for sports nutrition formulations focused on muscle development, strength support, and body composition management. It is well-suited for developing pre- and post-workout supplements and functional nutrition products targeting active individuals.
Betaine anhydrous cholesterol
Betaine anhydrous powder significantly reduces hepatic triglyceride accumulation and plasma total cholesterol levels induced by a high-sucrose diet by activating the hepatic AMPK signaling pathway and inhibiting the expression of SREBP-1c—a key transcription factor for lipogenesis—as well as downstream genes such as ACC and FAS. These findings indicate that betaine can serve as a betaine anhydrous supplement to regulate lipid metabolism and support liver health, making it particularly suitable for managing fat metabolism in individuals consuming high-sugar, high-fat diets. Research also confirms its wide safety margin, highlighting its promising potential for nutritional intervention.
In the development of functional foods and health supplements, betaine represents a viable functional ingredient for supporting hepatic lipid metabolism. For the animal feed industry, incorporating betaine into high-fat, high-sugar diets helps improve body fat distribution and blood lipid profiles through metabolic regulation, thereby enhancing production efficiency.
Betaine anhydrous for skin
Anhydrous betaine exhibits a significant inhibitory effect on melanogenesis. It functions through a dual mechanism: inhibiting melanogenesis by directly suppressing tyrosinase activity while also downregulating the gene expression of MITF and tyrosinase. As tyrosinase is the rate-limiting enzyme for the first two steps of melanogenesis, the development of most skin-lightening agents is based on inhibiting its activity.
Betaine anhydrous powder serves as a natural source of active ingredients for functional skincare products (designed for skin lightening or dark spot reduction) and oral beauty supplements.
What Is Betaine Anhydrous Powder Used For?
Trimethylglycine TMG supplement
Anhydrous betaine is a widely used ingredient in dietary supplements, with a strong safety profile at daily intakes of up to 4g. Supplementation supports liver health, helps maintain intestinal barrier integrity, improves adipose tissue function, and alleviates oxidative and endoplasmic reticulum stress; it also offers protective effects for the cardiovascular, nervous, and pancreatic systems, making it an excellent choice for the development of finished dietary supplement formulations.
Betaine anhydrous cosmetic
Betaine anhydrous is a mild yet highly effective skincare ingredient, widely used in cleansing and restorative products thanks to its excellent hygroscopic and penetrative properties. It regulates skin osmotic pressure, locks moisture into the stratum corneum for long-lasting hydration, and soothes dryness and tightness; simultaneously, it strengthens the skin barrier, alleviating discomfort caused by external irritants.
Betaine also boasts excellent compatibility, helping to mitigate the irritation often associated with surfactants and enhancing the gentleness of facial cleansers. Furthermore, it helps alleviate oxidative stress and maintain skin homeostasis; suitable for sensitive skin formulations, it is a common functional ingredient in cleansers, restorative serums, and moisturizing creams.
Betaine anhydrous in feed additives
Anhydrous betaine has been approved for continued use as a feed additive and is safe for all animal species, including swine, poultry, ruminants, and aquatic animals.
As a highly effective feeding stimulant, it boosts the appetite of fish and shrimp and improves feed utilization efficiency. Acting as an osmolyte, it enhances the resilience of farmed animals against environmental stressors such as sultry heat and rainfall. As a methyl donor, it can partially replace methionine, thereby optimizing feed formulation costs, while also preserving vitamin activity and extending shelf life. Additionally, it aids in the prevention of coccidiosis in poultry and supports intestinal health, contributing to improved farming profitability in multiple ways.
Betaine Anhydrous Powder Regulatory Status of EFSA
According to the latest scientific opinion issued by EFSA (European Food Safety Authority) in 2025, the authorization for betaine anhydrous (3a920) as a nutritional feed additive has been renewed for all animal species under existing conditions. EFSA confirmed its safety for target animals, consumers, and the environment, with a maximum recommended inclusion level of 2,000 mg/kg of complete feed (and in drinking water: 1,000 mg/L for poultry, 700 mg/L for pigs, and 250 mg/L for calves).
EFSA emphasized that this level should be established as a statutory maximum limit rather than merely a recommendation. No re-evaluation of efficacy was required. Regarding handling safety, anhydrous betaine is irritating to the skin and eyes; therefore, protective equipment must be worn during use.
Betaine Anhydrous Powder Side Effects
Anhydrous betaine demonstrates a favorable safety profile in clinical practice, with no new or potential safety risks identified. Adverse reactions include diarrhea, blurred vision, and extreme hypermethioninemia; these are generally mild and resolve rapidly upon dose reduction or discontinuation. Although rare, cerebral edema is a serious complication; blood methionine levels require monitoring, and the drug should be discontinued immediately if symptoms such as headache, vomiting, or visual changes occur. No dose-related safety issues have been observed, even at doses up to three times the recommended level, and the ingredient has demonstrated good overall tolerability.
Betaine Anhydrous Powder Dosage
Dosages of anhydrous betaine vary significantly depending on the intended application. Pharmaceutical applications typically involve higher doses, such as 6 g/day for adults in the management of homocystinuria, where betaine is used as an orphan drug therapy. Dosages for sports nutrition are lower; 2.5 g/day combined with resistance training can improve body composition and athletic performance, making it suitable as a functional sports supplement.
For animal feed, the European Food Safety Authority (EFSA) recommends an inclusion rate of 2,000 mg/kg in complete feeds for poultry and swine, a level well within safety limits. Cell-based studies serve primarily to elucidate mechanisms of action. Overall, anhydrous betaine has a broad safe dosage range (clinical safety has been demonstrated at 6–30 g/day for medical use), and the variations in dosage across different sectors reflect its multi-target regulatory properties; companies can select compliant dosage regimens based on their target markets.
Kintainutri® Betaine Anhydrous Powder Advantages
Kintainutri® offers efficient, large-scale supply of betaine anhydrous powder, ensuring exceptional batch-to-batch consistency. We maintain ready stock in 98% and 99% specifications, support rapid 24-hour dispatch, and provide comprehensive COA reports and compliance documentation with every shipment. Whether for samples or bulk orders, we offer competitive factory-direct pricing. Contact the Kintainutri® team today to request free samples and the latest quotes, and launch a highly efficient, stable long-term partnership.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Reference:
[1]: https://www.mdpi.com/2218-1989/14/7/390
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC3844502/
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8030815/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6049772/
[5]: https://pubmed.ncbi.nlm.nih.gov/35358327/
[6]: https://pubmed.ncbi.nlm.nih.gov/40276164/
[1]: https://www.mdpi.com/2218-1989/14/7/390
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC3844502/
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8030815/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6049772/
[5]: https://pubmed.ncbi.nlm.nih.gov/35358327/
[6]: https://pubmed.ncbi.nlm.nih.gov/40276164/
FAQ
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