Pharm Ingredients
Black Pepper Extract Piperine Powder
Black Pepper Extract Piperine Powder Manufacturers
Acclaimed as the "King of Spices," black pepper is widely cultivated in tropical and subtropical regions; its fruit is rich in various bioactive compounds, including sterols, fatty acids, terpenes, and amides. As a key functional ingredient, piperine is not only the primary source of black pepper's pungent flavor but also attracts significant attention due to its multi-target biological activity. Kintainutri® offers high-purity black pepper extract piperine powder (95% and 98% specifications) and supports customized specifications to facilitate the development of differentiated products for clients.
What is Black Pepper Extract Piperine Powder?
Piperine, also known as Bioperine, is a natural alkaloid derived from black pepper. It is primarily extracted from the dried near-ripe or mature fruits of piper nigrum L., a plant belonging to the Piperaceae family. Piperine is the key compound responsible for the characteristic spicy flavor of pepper and is found in various pepper plants. In the market, both black and white pepper contain piperine, with concentrations typically ranging from 5% to 9%, and sometimes reaching up to 11%.
In the field of nutrition and health, black pepper extract piperine powder effectively enhances the bioavailability of various nutrients and plant extracts by modulating enzyme activity and transporter function; regarding metabolic intervention, research confirms its role in helping to regulate lipid homeostasis; and in green agriculture, piperine and its derivatives demonstrate significant potential for controlling a wide range of agricultural pests. Leveraging its advantages as a natural raw material and its chemically modifiable structure, piperine is emerging as a preferred functional ingredient for dietary supplements and novel bio-based pesticides.
Black Pepper Extract Piperine Powder Chemical & Physical Properties
| CAS Number | 94-62-2 | Density | 1.0864 g/cm3 |
|---|---|---|---|
| Molecular Formula | C17H19NO3 | Molecular Weight | 285.34 |
| Melting Point | 131-135 ℃ (lit.) | Boiling Point | 427.77 ℃ (rough estimate) |
| Solubleness | 0.04 g/L | Test Method | HPLC |
Black Pepper Extract Piperine Powder COA
How To Make Black Pepper Extract Piperine Powder?
Black Pepper Extract Piperine Powder benefits:
Piperine benefits for men
Piperine, the key active component of black pepper extract, demonstrates clear potential for application in the field of men's health. A study involving male diabetic rats showed that black pepper extract significantly improved erectile function and libido while increasing the number of testicular Leydig cells. At higher dosages, sperm concentration, progressive motility, and the proportion of sperm with normal morphology were all significantly restored. These findings provide a scientific basis for developing dietary supplements containing piperine aimed at supporting male sexual health, reproductive nutrition, and athletic performance.
Piperine benefits for women
Piperine demonstrates multifaceted potential in the realm of women's health. It inhibits the proliferation of cervical cancer (HeLa) and ovarian cancer cells by downregulating the COX-2 pathway and activating p53 and mitochondrial apoptotic pathways to induce apoptosis. Additionally, it enhances sensitivity to chemotherapeutic agents, such as paclitaxel, and reverses drug resistance.
In melanoma models, piperine inhibits tyrosinase activity and melanogenesis in a dose-dependent manner, suggesting potential applications in skin-whitening products.Consequently, piperine holds broad prospects for the development of functional foods targeting women's reproductive health, nutritional support for cancer management, and skincare.
Piperine cancer
Piperine exhibits a multi-target mechanism of action in the fields of cancer prevention and adjuvant therapy. By modulating multiple pathways, such as inducing apoptosis, arresting the cell cycle, and inhibiting angiogenesis and epithelial-mesenchymal transition (EMT), piperine effectively suppresses the proliferation, migration, and metastasis of various cancer cell types, including breast, colorectal, lung, and prostate cancer cells.
Furthermore, as a natural P-glycoprotein inhibitor, piperine can reverse tumor multidrug resistance; when combined with chemotherapeutic agents (such as docetaxel, cisplatin, and doxorubicin), it produces a synergistic effect, thereby enhancing therapeutic efficacy and reducing side effects.
Piperine weight loss
Black pepper extract possesses multiple scientifically validated biological activities, including anti-inflammatory and antioxidant properties, as well as the ability to regulate glucose and lipid metabolism. Animal studies demonstrate that piperine significantly reduces high-fat diet-induced serum triglyceride, total cholesterol, and LDL levels while increasing HDL levels. It also effectively inhibits fat accumulation without suppressing appetite.
Human clinical trials confirm that a daily intake of 60 mg of piperine alleviates exercise-induced muscle damage and soreness. These findings indicate that Kintainutri® black pepper extract piperine powder is suitable for use in dietary piperine supplements targeting weight management, sports nutrition, and metabolic health.
What Is Black Pepper Extract Piperine Powder Used For?
Piperine supplement
Piperine dietary supplements offer a range of functions: first, acting as a natural bioavailability enhancer, it significantly boosts the absorption of curcumin, Coenzyme Q10, and various vitamins by inhibiting drug-metabolizing enzymes, making it a "gold-standard partner" for enhancing formulation efficacy; second, it supports weight management and metabolic regulation by lowering serum triglycerides and inhibiting fat accumulation without suppressing appetite, making it suitable for sports nutrition and fat-loss products; and third, it possesses anti-inflammatory and antioxidant properties, as well as therapeutic potential, by blocking inflammatory pathways and acting synergistically with anti-cancer drugs.
Piperine pesticides
Black pepper extract shows insecticidal potential in the field of green pesticides. Research indicates that piperine nano-formulations can significantly enhance larvicidal activity against Aedes aegypti. Their derivatives interfere with chitin metabolism and normal growth and development in pests, such as the Asian corn borer, diamondback moth, and fall armyworm, by inhibiting chitinase or trehalase, thereby exerting significant lethal and sublethal effects.
Notably, some derivatives achieve a 90% mortality rate against the diamondback moth at a concentration of 1.0 mg/mL. Characterized by highly modifiable structures and novel modes of action, piperine and its derivatives serve as promising lead compounds for the development of new bio-based pesticides, including green insecticides and synergistic combination products.
Black Pepper Extract Piperine Powder Side Effects And Dosage
According to a 2021 systematic review by the German Federal Institute for Risk Assessment, the intake of isolated piperine, particularly as a bolus dose, poses multiple potential health risks. Human studies indicate that a daily dose of 20 mg can significantly increase the bioavailability of various medications, such as antiepileptics and antihypertensives, while a dose of just 15 mg enhances the effects of sedatives, creating a risk of excessive pharmacological activity. Animal studies show that daily doses of 10–20 mg/kg body weight in females can reduce implantation rates, while 25 mg/kg can lead to miscarriage and stillbirth.
It is recommended that products containing piperine carry a warning advising individuals taking medication, as well as pregnant women and those planning a pregnancy, to avoid use. Furthermore, formulations should be adjusted in light of increasingly stringent regulations by referencing established limits in various jurisdictions (e.g., 10 mg/day in Australia, 14 mg/day in Canada, and an estimated 2.3 mg/day according to the BfR in Europe).
Where To Buy Black Pepper Extract Piperine Powder?
Kintainutri®'s black pepper extract piperine powder contains piperine as its primary active ingredient and is produced from high-quality Piper nigrum L. through a standardized extraction process. It is available in ≥95% and ≥98% purity grades. Piperine exhibits diverse biological activities, including antioxidant, antimicrobial, anti-inflammatory, gastroprotective, and antidepressant properties; it effectively scavenges free radicals and shows potential for applications in chemoprevention, the inhibition of tumor growth, and the improvement of cognitive function.
Our product rivals well-known piperine-based ingredients on the market (such as BioPerine®), offering comparable functional benefits. This ingredient is widely used in dietary supplements, functional foods, and pharmaceutical intermediates. Kintainutri® offers a stable supply of high-purity bulk piperine powder, supports customized specifications, and meets export standards. Please feel free to contact us for product specifications and samples.
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