Pharm Ingredients
Clary Sage Extract Sclareol Powder
What Is Clary Sage Extract Sclareol Powder?
As a supplier of sclareol powder, Kintainutri® offers sclareol with consistent quality (purity ≥95%) as well as sclareolide (purity ≥98%). Sclareol appears as a white crystalline powder and possesses a distinctive ambergris-like aroma. As an endogenous plant secondary metabolite, sclareol holds significant application value in fields such as high-end perfumery, cosmetics, and pharmaceutical R&D. Kintainutri® provides professional raw material support for your product development.
| Product Name/ Active Ingredient |
Source | Form | Best-Selling Specifications |
|---|---|---|---|
| Sclareol Powder | Clary Sage Extract | Powder | ≥95% |
| Sclareolide Powder | Clary Sage Extract | Powder | ≥98% |
Clary Sage Extract Sclareol Powder is a natural diterpene alcohol primarily synthesized and accumulated in the large capitate glandular trichomes of Salvia sclarea (clary sage) calyces. Research indicates that the isopentenyl pyrophosphate precursor for sclareol is derived mainly from the MEP pathway in plastids, rather than the MVA pathway in the cytoplasm. Studies using glabrous mutants have confirmed that large capitate glandular trichomes contribute over 93% of the total sclareol yield, serving as the primary site of its biosynthesis. As a key natural precursor for the synthesis of ambroxide, sclareol is widely used in the fragrance and flavor industry. This study provides systematic molecular biological evidence regarding the natural source and biosynthetic mechanism of sclareol.
Contact us
Clary Sage Extract Sclareol Powder Specification
| Test Item | Specification | Test Methods |
|---|---|---|
| Appearance | White Crystalline Powder | Visual |
| Odor | Characteristic | Organoleptic |
| Taste | Characteristic | Olfactory |
| Melting Point | 121°C – 124°C | CP2015 |
| Specific Rotation | +38° ~ +42° | CP2015 |
| Assay | ≥98.0% | GC |
| Loss on Drying | ≤0.5% | CP2015 (105°C, 3 h) |
| Ash | ≤0.3% | CP2015 (600°C, 4 h) |
| Heavy Metals | ≤10 ppm | CP2015 |
| Aerobic Bacterial Count | ≤1,000 cfu/g | CP2015 |
| Total Yeast & Mold | ≤100 cfu/g | CP2015 |
| Escherichia coli | Negative | CP2015 |
| Salmonella | Negative | CP2015 |
How Is Clary Sage Extract Sclareol Powder Made?
Currently, sclareol is primarily obtained from clary sage calyces via plant extraction. While this process is well-established, it faces supply stability challenges due to factors such as long cultivation cycles, low yields per acre, and climate dependency. In recent years, the biosynthetic pathway of sclareol powder has been fully elucidated: two diterpene synthases, SsLPPS and SsSS, cooperatively catalyze the conversion of GGPP into sclareol without the involvement of P450 enzymes.
Based on this discovery, the recombinant production of sclareol in yeast has been successfully achieved, offering a technical alternative to plant extraction. However, the commercialization of fermentation-based production remains constrained by issues such as patent barriers and the need for large-scale validation; consequently, plant extraction remains the dominant supply method. Kintainutri® sclareol is derived from plant extraction, ensuring consistent and reliable quality, and is suitable for applications in fragrances, flavors, and pharmaceutical intermediates.
Please feel free to contact us for further information.
Clary Sage Extract Sclareol Powder Benefits
Sclareol For Cancer
Sclareol exhibits broad-spectrum antiproliferative activity against various cancer cell lines, including leukemia, breast, colon, cervical, osteosarcoma, and lung cancer cells, with IC₅₀ values in the micromolar range. Its mechanisms of action involve inducing G0/G1 cell cycle arrest, causing DNA damage, disrupting mitochondrial membrane potential, and activating both intrinsic and extrinsic apoptotic pathways through the upregulation of p53, BAX, and caspase-8/9 and the downregulation of Bcl-2.
Furthermore, sclareol enhances sensitivity to chemotherapeutic agents such as cisplatin and doxorubicin, reverses tumor drug resistance, inhibits tumor growth in animal models, and modulates the tumor immune microenvironment. As a natural diterpene alcohol, Clary Sage Extract Sclareol Powder holds potential value for the development of anti-tumor drugs and agents that sensitize tumors to chemotherapy.
Sclareol For Women
Sclareol is a natural diterpene alcohol derived from Salvia sclarea that shows significant potential for alleviating menstrual pain. It exerts uterine-relaxing effects by inhibiting excessive contractions of uterine smooth muscle induced by prostaglandin F2α and oxytocin, while also interfering with calcium signaling pathways through the downregulation of proteins such as the oxytocin receptor, myosin light-chain kinase (MLCK), and phosphorylated myosin light chain 20 (p-MLC20).
Furthermore, sclareol inhibits COX-2 expression and reduces oxidative stress, providing complementary anti-inflammatory and analgesic effects. These findings provide a scientific basis for exploring Kintainutri® sclareol powder as a functional ingredient for women's menstrual health products.
What Is Clary Sage Extract Sclareol Powder Used For?
Sclareol in the Fragrance and Flavor Industry
Sclareol is a key natural precursor for the synthesis of Ambroxide (Ambrox) in the fragrance and flavor industry. As a sustainable alternative to natural ambergris, Ambroxide features a long-lasting musky, sweet, and earthy aroma and is widely used as a fixative in high-end perfumes, cosmetics, and tobacco flavoring. The two hydroxyl groups in sclareol confer high chemical reactivity, enabling various semisynthetic modifications to produce valuable fragrance compounds. It is widely used in premium perfumes, soaps, cosmetics, and tobacco flavoring applications.
In Animal Nutrition and Feed Additives
Clary sage extract demonstrates the potential to improve intestinal health and immune function in lambs. Dietary supplementation with clary sage extract modulates gut microbiota composition and reduces the abundance of potentially harmful bacteria; simultaneously, it upregulates serum antioxidant metabolite levels and activates pathways related to nucleotide metabolism, fatty acid synthesis, and oxidative stress.
Correlation analysis between microbiota and metabolites further reveals its role in regulating host energy metabolism and immune responses. As a natural plant extract, clary sage extract helps alleviate weaning stress and promotes healthy growth in lambs, making it a functional feed additive with significant development potential.
Sclareol in Cosmetics
Sclareol is widely used in the cosmetics and personal care sectors. In aromatherapy, clary sage essential oil is utilized to relieve stress and improve mood. Regarding skincare, sclareol offers anti-photoaging benefits; it inhibits UV-induced MMP expression and prevents collagen degradation, with clinical trials confirming that creams containing 0.02% sclareol can reduce the appearance of wrinkles. Additionally, clary sage essential oil possesses anti-inflammatory and antimicrobial properties, making it suitable for soothing sensitive skin and improving overall skin condition. In personal care products, sclareol also serves as a fragrance ingredient, imparting a long-lasting scent to perfumes, lotions, bath products, and more.
Sclareol in the Pharmaceutical Field
Sclareol demonstrates multi-target therapeutic potential across a range of pharmaceutical applications. In cancer research, it has shown inhibitory effects against various cancer cell types, including leukemia, breast, colon, cervical, osteosarcoma, and lung cancer cells, while also enhancing the sensitivity of certain cancer cells to chemotherapeutic agents. Its anti-inflammatory activity has been investigated in conditions such as atopic dermatitis, arthritis, and lung injury, where it may help alleviate inflammatory responses. In women's health, sclareol has demonstrated potential for relieving menstrual pain. Furthermore, it exhibits antimicrobial activities, including antifungal, antischistosomal, and anti-Ebola virus effects, while preliminary research has also explored its potential applications in Parkinson's disease and COVID-19.
Safety of Clary Sage Extract Sclareol Powder
Sclareol is classified as a non-hazardous chemical under OSHA (Occupational Safety and Health Administration) hazard classifications and does not require special hazard labeling. Toxicological data indicate low toxicity, with no observed signs of skin corrosion, eye irritation, sensitization, or mutagenicity. It is not listed as a carcinogen by authoritative bodies such as IARC, NTP, ACGIH, or OSHA, nor does it contain known or suspected endocrine disruptors. Sclareol is listed in major chemical inventories, including the US TSCA, European EINECS, and Canadian DSL, and complies with international chemical management requirements. No special protective measures are required under normal handling and operating conditions; however, contact with strong oxidizing agents and strong acids should be avoided.
Health Canada: According to the summary of information and assessment regarding sclareol published by the Canadian government, the substance is primarily used as an ingredient in cosmetics, fragrances, aromatherapy products, and flavorings. The assessment concludes that, although sclareol exhibits potential persistence and bioaccumulation, its annual import or production volume in Canada is extremely low (not exceeding 100 kg), and actual environmental releases remain below levels that would cause harm to organisms. Therefore, at current exposure levels, sclareol poses no risk to human health or the environment; it is suitable for conventional uses such as cosmetics and fragrances and complies with Canadian chemical management requirements.
Sclareol (CAS 515-03-7) has undergone a safety assessment by the Research Institute for Fragrance Materials (RIFM), and its safety as a fragrance ingredient in cosmetics and consumer products is recognized by the industry. Conducted by the RIFM Expert Panel based on scientific data, this assessment serves as a safety endorsement for the widespread use of sclareol in the fragrance industry. As a natural diterpene alcohol, sclareol can be used in fragrance formulations for personal care products such as perfumes, skincare items, and bath products.
Kintainutri® Clary Sage Extract Sclareol Powder Advantages
Thanks to its unique aromatic profile and beneficial biological activity, clary sage extract sclareol powder shows great promise for application in the fragrance, cosmetics, and pharmaceutical R&D sectors. As a key raw material for synthesizing ambroxide, it plays an irreplaceable role in high-end perfumes and personal care products. Meanwhile, research into the anti-tumor, anti-inflammatory, and antimicrobial properties of sclareol is expanding rapidly.
Kintainutri® Sclareol (purity ≥95%) offers stable quality and excellent batch-to-batch consistency, making it ideal for formulation development in the fragrance, cosmetics, and pharmaceutical industries. We are committed to providing our customers with professional technical support and reliable supply chain services. Please feel free to contact us for more information or to request samples.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Reference:
[1]: https://www.nature.com/articles/s41438-021-00640-w
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC3520730/
[3]: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1014105/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC7602146/
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC13210186/
[6]: https://www.canada.ca/en/health-canada/services/chemical-substances/challenge/batch-12/sclareol.html
[7]: https://www.sciencedirect.com/science/article/abs/pii/S0278691526002073?via%3Dihub
[1]: https://www.nature.com/articles/s41438-021-00640-w
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC3520730/
[3]: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1014105/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC7602146/
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC13210186/
[6]: https://www.canada.ca/en/health-canada/services/chemical-substances/challenge/batch-12/sclareol.html
[7]: https://www.sciencedirect.com/science/article/abs/pii/S0278691526002073?via%3Dihub
About Us
