Pharm Ingredients
Diosgenin Powder
Dioscorea Villosa Wild Yam Root Extract Powder Manufacturers
Diosgenin serves as a crucial raw material for the synthesis of steroidal hormone drugs—such as progesterone, and is also an excellent precursor for the production of adrenocortical hormones. Diosgenin's primary source is Dioscorea nipponica species, including varieties such as Turmeric, wild yam.
These plants are predominantly distributed across the Chinese provinces of Shaanxi, Gansu, and Henan, with additional distribution found in regions north of Honshu, Japan, as well as in Korea. 6-Ketodiosgenin is a derivative of diosgenin in which a keto group has been introduced, it can be extracted directly from specific plant species (such as Dioscorea nipponica) or synthesized using diosgenin produced by our company.
As a specialized extraction company focused on diosgenin, Kintainutri® is strategically located in Xi'an—the provincial capital of Shaanxi, China. Benefiting from this advantageous geographical location, we are able to supply our clients with premium-quality diosgenin powder, underpinned by the use of superior raw materials. Leveraging a robust R&D team and sophisticated extraction technologies, our company is capable of providing diosgenin products with purity levels ranging from 90% to 98%.We can also customize the specifications you require based on your needs.
Diosgenin Powder Specification
| Item | Specifications | Test Method |
|---|---|---|
| Assay (Diosgenin) | Diosgenin≥98.0% | HPLC |
| Appearance | White or off white powder | Visual |
| Odor&Taste | Characteristic | Organoleptic |
| Identification | Positive | TLC |
| Residue on ignition | ≤5.0% | GB 5009.4-2016 |
| Loss on Drying | ≤3.0% | GB 5009.3 |
| Mesh Size/Sieve | 98% pass 80 mesh | Sieve Test |
| Extract solvent | Ethanol & water | Gas Chromatography (GC) |
| Heavy Metals | ≤10 ppm | AAS |
| Arsenic (As) | ≤1 ppm | GB 5009.268 |
| Lead (Pb) | ≤2 ppm | GB 5009.268 |
| Mercury (Hg) | ≤100 ppm | GB 5009.268 |
| Cadmium (Cd) | ≤2 ppm | GB 5009.268 |
| Total Plate Count | ≤1000cfu/g | GB 4789.2-2022 |
| Total Yeast &Mold | ≤100cfu/g | GB 4789.15-2016 |
| E.Coli. | Negative | GB 4789.3 |
| Salmonella | Negative | GB 4789.4 |
| Storage | Cool & dry place.Do not freeze .Keep away from light and heat. | |
| Package | Store in tightly closed plastic bag and keep in a cool dry place. | |
| Shelf life | 24 month | |
Extraction Of Diosgenin Powder From Dioscorea
Diosgenin is obtained through the isolation, purification, and extraction of the Dioscorea nipponica plant. Kintainutri® employs advanced processing techniques for Dioscorea nipponica. Specifically, it utilizes professional supercritical CO₂ extraction technology to preserve the active constituent—diosgenin—while refining the product. The material subsequently undergoes concentration and drying to yield a fine powder.
Dioscorea Villosa Wild Yam Root Extract Powder Benefits
Pharmacological actions
●Numerous studies have demonstrated that dioscin holds significant research value as a potential anti-tumor and anti-cancer agent . The known anti-cancer mechanisms of diosgenin involve the modulation of various cellular signaling pathways—pathways implicated in cell growth, proliferation, differentiation, epithelial-mesenchymal transition (EMT), migration, and apoptosis, as well as in tumorigenesis and angiogenesis.
Consequently, dioscin plays a pivotal role in inducing apoptosis and preventing malignant transformation, exhibiting inhibitory effects against a wide spectrum of cancer cells, including those associated with prostate, colon, breast, lung, and liver cancers as well as leukemia.
Consequently, dioscin plays a pivotal role in inducing apoptosis and preventing malignant transformation, exhibiting inhibitory effects against a wide spectrum of cancer cells, including those associated with prostate, colon, breast, lung, and liver cancers as well as leukemia.
Accordingly, we offer our product—a promising therapeutic agent for cancer treatment—to research institutions and relevant enterprises for use in their studies.
●The anti-inflammatory activity of diosgenin is widely recognized, and it has demonstrated therapeutic potential in various inflammation-related diseases. Diosgenin modulates the expression of adipokines in perivascular adipose tissue by regulating AMPK, thereby ameliorating endothelial dysfunction, this mechanism explains how diosgenin protects endothelial function against inflammatory damage. Diosgenin powder holds significant research value for relevant medical studies and shows promise for use in the targeted treatment of osteoarthritis and rheumatoid arthritis. 
●Diosgenin is a potential candidate drug for treating diabetic kidney complications. It acts on the pancreas, liver, skeletal muscle, and adipose tissue, regulating metabolic mechanisms and improving diabetes in obese patients with type 2 diabetes by increasing adipocyte differentiation and inhibiting adipose tissue inflammation. Studies have indicated that it can restore insulin sensitivity, glucose homeostasis, and normal blood lipid levels in diabetic animals. The evidence indicates that diosgenin can enhance the action of insulin in peripheral tissues and synergistically increase insulin secretion while reducing the activity of glucokinase in the liver and improving glucose metabolism.
Diosgenin bodybuilding and muscle growth
Dioscin promotes skeletal muscle differentiation and inhibits muscle atrophy, demonstrating potential as a therapeutic agent for protecting muscle cells against oxidative damage. Diosgenin may stimulate the intramuscular synthesis of DHT and testosterone, thereby activating the Akt/mTOR/p70S6K pathway to promote muscle protein synthesis and hypertrophy. An increase in testosterone concentration leads to enhanced uptake and utilization of testosterone by muscle cells, this process stimulates protein synthesis—enabling muscles to effectively absorb protein—and consequently boosts muscle accretion and strength. Ultimately, it can more effectively improve muscle thickness, muscle mass, muscle function, and cardiovascular-metabolic markers in healthy middle-aged and elderly individuals
What Is Diosgenin Powder Used For
Diosgenin powder medicinal uses
Diosgenin is a naturally occurring compound exhibiting multi-target activity. As a pivotal steroidal sapogenin, its potent pharmacological effects gave it medicinal uses. By virtue of its powerful and diverse pharmacological actions, diosgenin powder serves as a key raw material for the synthesis of steroidal hormones (including progesterone, corticosteroids, and other steroid-based pharmaceuticals). Furthermore, it holds promise as a potential therapeutic agent for a wide range of chronic diseases—including various cancers such as breast cancer and chronic myelogenous leukemia. Consequently, our product is poised for extensive application within the pharmaceutical industry as diosgenin tablets.
Diosgenin powder foods and supplement
Steroidal saponins—naturally occurring in plants such as Dioscorea nipponica—are derived from raw materials that possess significant dietary value in their own right, a prime example is the yam, which is rich in diosgenin. 
Based on the principles of Traditional Chinese Medicine—specifically the concept that "medicine and food share a common origin"—these ingredients serve as raw materials endowed with vital pharmacological properties, including the strengthening of the spleen and stomach, the enhancement of immunity, and the delay of aging. Their unique efficacy and distinct flavor profile hold immense appeal for consumers. Consequently, diosgenin supplements have gained widespread popularity in the market as a novel category of health products that emerged recently.
To take advantage of this market demand, our company uses advanced methods—like extracting diosgenin from yams—to turn these raw materials into products ready for sale as functional foods and nutritional supplements. This strategic approach not only demonstrates the viability of our business model but also underscores the promising market outlook and significant growth potential inherent in diosgenin powder.
Diosgenin Powder Side Effects And Safety
As a natural extract derived from plants, diosgenin is safe within normal usage ranges, the traditional dosage for steroidal saponins is 5–10 mg/kg/day. In a study involving breast cancer cells, results indicated that dioscin regulates their survival by modulating AKT. Furthermore, the compound demonstrated no adverse effects on normal breast epithelial cells (MCF-10A), exhibiting selective toxicity solely toward cancer cells. Research has confirmed that diosgenin and its derivatives are non-toxic, thereby affirming its therapeutic value in the treatment of chronic diseases, including cancer.
Kintainutri® Diosgenin Powder Advantages
Kintainutri® boasts a stable supply chain for diosgenin raw materials, leverages the advantages of natural source regions, employs mature modern extraction technologies (specifically supercritical CO₂ extraction), and maintains a comprehensive quality management system. Our products serve as foundational raw materials for pharmaceuticals, as well as key sources of active ingredients for functional foods, sports nutrition, and anti-aging products.
We can extract diosgenin with different levels of purity—from 16% to 98%—using various sources like turmeric and wild yam, so we can meet the different needs of our clients. Our company provides customers with pharmaceutical-grade raw materials and customized formulation support while also offering third-party testing reports (COAs), stability study data, and regulatory compliance documentation (GMP, ISO), ensuring a stable, high-quality, and comprehensive service across the entire supply chain.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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FAQ
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Does diosgenin increase testosterone？
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