Pharm Ingredients
Indole 3 Carbinol I3C Powder
Indole 3 Carbinol I3C Powder Manufacturers & Supplier
Kintainutri® specializes in supplying high-purity (≥98%) Indole-3-Carbinol powder in bulk quantities. With consistent quality, our product is suitable for use in dietary supplements, as well as in certain pharmaceutical and personal care products. We are dedicated to delivering high-specification Indole-3-Carbinol powder to global customers through professional and reliable service, helping to elevate products and brands within the health industry.
| Product Name | Source | Best-selling Specifications |
|---|---|---|
| Indole-3-Carbinol Powder | Synthesis | |
| 98% | ||
| 99% |
Indole-3-carbinol (I3C) is an active phytochemical naturally found in cruciferous vegetables. When the cells of vegetables such as broccoli, cabbage, cauliflower, and kale are disrupted, the glucosinolates (specifically glucobrassicin) they contain are enzymatically converted into I3C. Research indicates that indole-3-carbinol shows promising potential in providing antioxidant effects, regulating hormone metabolism, and supporting cellular health.
Indole 3 Carbinol I3C Powder Specification
| ITEMS | SPECIFICATIONS | TEST METHOD |
|---|---|---|
| Assay | ≥98.0% | HPLC |
| Appearance | Off-White Crystal Powder | Visual |
| Odor&Taste | Characteristic | Visual&Taste |
| Particle Size | 100% Through 80 Mesh | USP |
| Loss on Drying | ≤1.0% | USP |
| Ash | ≤1.0% | USP |
| Pesticide Residue | Meets the requirement | USP |
| Residual Solvent | Meets the requirement | EP |
| Heavy Metals | ≤10ppm | USP |
| Arsenic | ≤2ppm | ICP-MS |
| Mercury | ≤0.1ppm | ICP-MS |
| Cadmium | ≤1ppm | ICP-MS |
| Lead | ≤2ppm | ICP-MS |
| Total plate count | ≤1000cfu/g | USP |
| Mould&Yeast | ≤100cfu/g | USP |
| E.Coli | Negative | USP |
| Salmonella | Negative | USP |
| Staphylococcus | Negative | USP |
How To Make Indole 3 Carbinol I3C Powder?
Indole 3 Carbinol I3C Powder Benefits
Indole 3 carbinol benefits for women
1. Indole 3 carbinol and estrogen
Indole-3-carbinol (I3C) plays a vital role in regulating estrogen metabolism. It induces CYP1A1/CYP1A2 enzyme activity, promoting the conversion of estradiol (E2) into 2-hydroxyestrogens while inhibiting the formation of 16-α-hydroxyestrogens. The former possesses low pharmacological activity and minimal carcinogenic risk, whereas the latter retains potent estrogenic activity. By increasing the 2-OHE1/16α-OHE1 ratio, I3C powder helps reduce estrogen-related health risks and supports endocrine balance in women. Kintainutri® provides high-quality raw materials for functional foods and dietary supplements aimed at women's health.
2. Indole-3-carbinol recurrent respiratory papillomatosis
Kintainutri®’s indole-3-carbinol (I3C) powder and its in vivo metabolite, DIM, demonstrate potential for application in HPV-related lesions. Research indicates that I3C can optimize the balance of estrogen metabolism, thereby reducing the risk of HPV-associated pathogenesis. In models of recurrent respiratory papillomatosis (RRP), I3C exhibits therapeutic potential by modulating the host cell microenvironment rather than through direct antiviral action. For brands focused on women's health and adjunctive interventions for HPV, our powder product represents a distinctive functional ingredient worthy of consideration.
Indole 3 carbinol benefits for men
Indole 3 carbinol supports prostate health through a multi-dimensional approach involving the regulation of hormone balance. In androgen-dependent prostate cancer cells, I3C and its metabolite DIM downregulate androgen receptor (AR) expression and inhibit cyclin D1 and CDK4, thereby blocking androgen-driven cell proliferation.
Regarding hormone metabolism, animal studies have demonstrated that indole 3 carbinol selectively modulates P450 enzyme-mediated testosterone hydroxylase activity by increasing testosterone 6α-hydroxylase activity while inhibiting 6β-hydroxylase activity, indicating a differential regulatory effect on androgen metabolic pathways.Additionally, I3C inhibits Akt phosphorylation and NF-κB activity, induces apoptosis in prostate cancer cells, and enhances chemosensitivity. Our high-purity indole-3-carbinol powder serves as a scientifically backed, multi-target, and differentiated ingredient for formulations supporting men's health and prostate function.
Indole-3-carbinol benefits weight loss
I3C offers multiple mechanistic advantages in the field of weight management. In vitro studies demonstrate that I3C reduces lipid droplet accumulation in adipocytes and inhibits adipocyte-induced angiogenesis in endothelial cells, thereby intervening in adipose tissue expansion at the source. Additionally, I3C activates thermogenesis, suppresses adipogenesis, and ameliorates the chronic low-grade inflammation associated with obesity.
Animal studies confirm that indole-3-carbinol powder prevents high-fat diet-induced obesity and shows potential in alleviating obesity-related complications, such as type 2 diabetes and atherosclerosis. I3C powder serves as a differentiated ingredient choice for functional foods targeting weight management and metabolic health.
Indole 3 carbinol cancer
I3C exerts anti-tumor activity through a multi-target mechanism: it inhibits CDK expression, leading to G1 phase cell cycle arrest in cancer cells; blocks the NF-κB signaling pathway by inhibiting elastase activity; and inhibits HECT-family E3 ubiquitin ligases (NEDD4/WWP1), thereby reactivating the PTEN tumor suppressor and blocking PI3K-Akt oncogenic signaling. Additionally, it promotes DNA repair (upregulating BRCA1/2 and RAD51) and induces cancer cell apoptosis, serving as a reliable ingredient for scientific research and functional formulations.
What Is Indole 3 Carbinol I3C Powder Used For?
Indole 3 carbinol supplement
I3C occurs naturally only in trace amounts in Brassica vegetables (such as broccoli) and is highly heat-labile; as dietary intake alone often fails to meet functional requirements, supplementation serves as a more reliable source. Commercially available products primarily come in capsule, tablet, and powder forms. While the standard recommended adult dosage ranges from 200 to 400 mg per day, specific intake should be adjusted based on individual needs and product specifications. Kintainutri® offers high-purity (≥98%) I3C powder suitable as a core ingredient for functional supplements and compound formulations, enabling brands to develop differentiated products tailored to their target demographics.
Personal Care and Pharmaceuticals
I3C is a molecule of significant interest in biomedical research, with potential applications targeting hormone-sensitive tumors, such as breast and prostate cancers, as well as HPV-related lesions and respiratory papillomatosis. it holds promise for development as an adjuvant cancer therapy or a chemopreventive agent.
In the personal care sector, leveraging its antioxidant and anti-inflammatory properties, I3C powder is being explored for use in anti-aging skincare, reparative serums, and hair care products. It helps neutralize free radicals, soothe inflammation, and support the skin barrier and scalp microenvironment, offering a differentiated ingredient choice for both pharmaceutical R&D and functional personal care products.
Indole 3 Carbinol I3C Powder Dosage
The recommended scientific dosage for Indole-3-Carbinol (I3C) powder is 200–400 mg daily, varying based on the specific application and target population; this range has been proven safe and effective in numerous human studies. In the context of women's health, research on breast cancer risk prevention indicates that 300 mg daily is the minimum effective dose for modulating estrogen metabolism, while a 400 mg daily regimen is also widely used and well-tolerated. Studies on cervical dysplasia (CIN) show that both 200 mg and 400 mg daily significantly promote the normalization of cervical tissue, with efficacy observed even at the 200 mg level. Research regarding breast hyperplasia demonstrates that 400 mg daily (taken over six menstrual cycles) can significantly alleviate cyclical breast pain.
For men's health, a daily intake of 200–400 mg serves as a reference dosage to support healthy prostate cell function. It is recommended to take the supplement with or after meals to improve tolerability; concurrent use of antacids or proton pump inhibitors may affect its efficacy.
Is Indole 3 Carbinol I3C Powder Safe?
Indole-3-Carbinol (I3C) powder is generally well-tolerated, with side effects being infrequent and mild. Common issues may include transient gastrointestinal discomfort, such as bloating or diarrhea, particularly upon initial use or at higher dosages (e.g., single doses of ≥600 mg).
However, the following safety considerations warrant close attention from brands during product development and consumer communication: use is not recommended for pregnant women or those planning to conceive (animal studies suggest potential impacts on the reproductive development of male offspring), and individuals with existing cancer should consult a physician before use. Theoretically, the hormonal regulatory mechanism of I3C could affect the efficacy of estrogen-related medications (such as oral contraceptives or hormone replacement therapy) and potentially influence bone metabolism in postmenopausal women; however, these hypotheses have not yet been confirmed by clinical studies and require further research for validation.
Where Can I Buy Indole 3 Carbinol I3C Powder?
As a professional supplier of Indole-3-Carbinol raw materials, Kintainutri® is dedicated to providing global brands, R&D institutions, and manufacturers with high-purity (≥98%) and fully traceable Indole-3-Carbinol (I3C) powder. We offer bulk supply options, with products meeting industry quality standards and suitable for applications in dietary supplements, functional foods, and pharmaceutical R&D. Choosing Kintainutri® means partnering with a reliable, compliant, and fully traceable raw material supplier. Please contact our sales team to obtain product specifications, samples, and bulk quotations.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Reference:
[1]: https://www.sciencedirect.com/science/article/pii/S002231662303198X?via%3Dihub
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9960368/#sec2-pharmaceuticals-16-00240
[1]: https://www.sciencedirect.com/science/article/pii/S002231662303198X?via%3Dihub
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9960368/#sec2-pharmaceuticals-16-00240
FAQ
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Does indole 3 carbinol powder lower estrogen?
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Can indole 3 carbinol cause cancer?
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Can you take dim and indole 3 carbinol together?
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