Pharm Ingredients
L Theanine Powder
L Theanine Powder Manufacturers
Kintainutri® has overcome the capacity limitations of traditional green tea extraction to achieve large-scale production of L-theanine with an ultra-high purity of 98%. The product aligns perfectly with the rigorous quality and stability standards required for dietary supplements and various other applications, providing global customers with innovative, cost-effective active ingredients backed by ample production capacity.
L-Theanine powder is a non-protein amino acid naturally found in green tea. Structurally similar to glutamate, an excitatory neurotransmitter in the brain, it can cross the blood-brain barrier and exert neuromodulatory effects. Widely used in dietary supplements and function al foods for applications ranging from sleep support and anti-anxiety benefits to cognitive enhancement, L-Theanine serves as a premium natural ingredient for brands seeking to create differentiated health products.
L Theanine Powder Specification
| Item | Specification | Method | |
|---|---|---|---|
| Appearance | White Powder | Visual | |
| Particle size | ≥95% through 80 mesh | Screening | |
| Residue on Ignition | ≤1g/100g | 3g/550℃/4hrs | |
| Loss on Drying | ≤5g/100g | 3g/105℃/2hrs | |
| Identification | Conforms with TLC | TLC | |
| Content | 98% L‑Theanine | HPLC | |
| Residue Analysis | |||
| Heavy Metals | ≤10mg/kg | ‑ | |
| Lead (Pb) | ≤1.00mg/kg | ICP‑MS | |
| Arsenic (As) | ≤1.00mg/kg | ICP‑MS | |
| Cadmium (Cd) | ≤1.00mg/kg | ICP‑MS | |
| Mercury (Hg) | ≤0.50mg/kg | ICP‑MS | |
| Microbiological Tests | |||
| Total Plate Count | ≤1000cfu/g | AOAC 990.12 | |
| Total Yeast & Mold | ≤100cfu/g | AOAC 997.02 | |
| E.Coli. | Negative/10g | AOAC 991.14 | |
| Salmonella | Negative/10g | AOAC 998.09 | |
| S.aureus | Negative/10g | AOAC 2003.07 | |
| Product Status | |||
| Conclusion | Sample Qualified. | ‑ | |
| Shelf Life | 24 months under the conditions below and in its original packaging. | ‑ | |
| Retest date | Retest every 24 months under the conditions below and in its original packaging. | ‑ | |
| Storage | Store in a cool, dry place away from Moisture, Light. | ‑ | |
How To Make L Theanine Powder?
L Theanine Powder Benefits
L-Theanine For Sleep
Due to its structural similarity to glutamate, L-theanine blocks excitatory receptors in the central nervous system while upregulating GABA receptor expression and promoting the secretion of serotonin, dopamine, and melatonin; consequently, it shortens sleep onset latency and extends the duration of non-rapid eye movement (NREM) sleep. Animal studies have confirmed that it antagonizes caffeine-induced excitation, enhances the activity of antioxidant enzymes such as SOD and CAT, reduces oxidative stress, and provides neuroprotective benefits.
When combined with magnesium, it further increases slow-wave power, a key indicator of deep sleep, demonstrating a significant synergistic effect. As a naturally derived non-protein amino acid, L-theanine is safe and non-habit-forming; it is well-suited for long-term health management and serves as a high-quality sleep-supporting ingredient in functional foods and dietary supplements.
L Theanine ADHD
L-theanine acts synergistically with caffeine to enhance sustained attention and overall cognitive performance in children with ADHD by reducing task-related “mind-wandering,” an effect mediated by the attenuation of task-related reactivity within the default mode network (DMN). Additionally, this combination improves inhibitory control, a benefit linked to the modulation of central executive network (CEN) activity. As a naturally derived amino acid with a favorable safety profile, L-theanine provides a scientific basis for developing dietary supplements aimed at supporting focus in children with ADHD; it is suitable for various dosage forms, such as chewable tablets and solid beverage mixes, thereby meeting the demands of the cognitive health market segment.
L Theanine For Anxiety
L-Theanine exerts an anxiolytic effect by modulating the central nervous system. Upon crossing the blood-brain barrier, it competitively inhibits the binding of glutamate to AMPA, kainate, and NMDA receptors, thereby reducing excitatory neurotransmission. Simultaneously, it promotes the release of the inhibitory neurotransmitter GABA, upregulates GABA receptor expression, and enhances alpha brain wave power in the cerebral cortex, inducing a state of relaxation.
Furthermore, L-Theanine inhibits the overactivation of the hypothalamic-pituitary-adrenal (HPA) axis and reduces cortisol secretion under stress, thereby alleviating psychological stress and tension; it is suitable for healthy individuals facing acute or chronic stress and serves as an excellent natural ingredient for anxiolytic functional foods and dietary supplements.
L Theanine For Dogs
As a natural amino acid derived from green tea, L-theanine offers a safe and effective adjunctive solution for noise sensitivity and thunderstorm phobia in dogs. Structurally similar to glutamate, it crosses the blood-brain barrier and modulates the central nervous system by increasing levels of the inhibitory neurotransmitter GABA and promoting the release of serotonin and dopamine, thereby alleviating anxiety and fear-related behaviors during thunderstorms.
Unlike traditional sedatives (such as phenothiazines), L-theanine is well-tolerated and free from severe sedative side effects; it is suitable for use in formulations such as calming chews and functional treats, making it an ideal natural anti-anxiety ingredient for the pet health market.
L Theanine Pregnancy
L-Theanine demonstrates significant metabolic benefits in a model of gestational obesity by modulating gut microbiota composition and bile acid metabolism. Its mechanism involves activating the FXR/FGF15 signaling pathway, repairing intestinal barrier damage induced by a high-fat diet and fecal microbiota transplantation from obese donors, reducing the expression of inflammatory factors and Claudin-2, and mitigating endotoxin translocation.
Concurrently, it downregulates the hepatic expression of lipid synthesis genes, such as CD36, SREBP1c, and SCD1, thereby alleviating insulin resistance and disorders of glucose and lipid metabolism. Furthermore, L-Theanine mitigates abnormal thickening of the placental junctional zone, reduces fetal body weight, and improves adverse pregnancy outcomes. As a naturally derived functional amino acid with a favorable safety profile, L-Theanine is suitable for development as a functional food ingredient for maternal health management.
What Is L Theanine Powder Used For?
L Theanine Powder Supplement
L-Theanine powder is a natural, functional amino acid supplement derived from green tea; it offers high purity and excellent water solubility, allowing for versatile incorporation into beverages or foods. The recommended daily intake is 100–200 mg; consumption before bedtime helps relax the body and mind and improves sleep quality, while daytime use alleviates stress and supports focus. Clinical studies have confirmed a wide safety margin and good tolerability, making it suitable for long-term health maintenance.
L Theanine Powder Drink
L-Theanine powder boasts excellent water solubility, making it compatible with various liquid formulations such as water, fruit juice, dairy beverages, and protein shakes. With a recommended dosage of 100–200 mg per serving, it can be used to develop functional beverages designed for either daytime stress relief and focus maintenance or pre-sleep relaxation and sleep support. The product has a mild taste that does not alter the flavor profile of the base beverage; it is well-tolerated by the body and causes no drowsiness. It is ideally suited for the formulation of functional drinks, ready-to-drink (RTD) beverages, and powdered drink mixes, helping companies create differentiated products that promote mind-body balance.
L Theanine Powder Dosage
| Item | Content |
|---|---|
| Proposed Dosage / Specification | Sublingual tablet 2.5mg, topical cream 10%, injection 75mg/7.5mL (10mg/mL), oral capsule 50/100/200mg |
| Oral Dosages Used in Clinical Studies | Healthy adults: 50‑600 mg/day, single dose up to 6 weeks; adult patients: 50‑900 mg/day, 35 days‑20 weeks; children: 100‑400 mg/day or 2.5mg/kg, 4 days‑8 weeks |
| Common Dosage in Food / Dietary Supplements | GRAS recognized, maximum 250 mg per serving |
| Pharmacokinetic Parameters (Oral) | Tmax approx. 50 min; absorption half‑life approx.15 min; elimination half‑life approx.65 min; exposure (Cmax and AUC) is proportional to dosage |
L-Theanine demonstrates significant value as an adjunct therapy for children with ADHD. Clinical studies indicate that when combined with caffeine, it markedly enhances overall cognitive function and attentional performance in these children; furthermore, a daily 400 mg dose used alone effectively improves sleep efficiency and subjective sleep quality, with a favorable safety profile and no serious adverse reactions.
Is L Theanine Powder Safe?
According to FDA review documents and clinical study data, L-theanine is generally well-tolerated at common oral dosages. Side effects reported in clinical studies primarily include gastrointestinal discomfort (nausea, diarrhea, constipation, loss of appetite), neurological symptoms (headache, drowsiness, agitation, increased dreaming), and tachycardia. Reports of serious adverse events are extremely rare; most occurred in the context of combination products or concomitant medication use, making it difficult to attribute them solely to L-theanine. Overall, side effects associated with L-theanine are mild and infrequent, and the substance possesses a wide safety margin.
Where To Buy L Theanine Powder?
As a specialized manufacturer of high-potency plant extracts and pharmaceutical intermediates, Kintainutri® maintains a rigorous quality control system; our facilities hold multiple international certifications, including GMP, ISO22000, HALAL, and KOSHER. We provide comprehensive supporting documentation (COA, MSDS), accommodate orders starting from 1 kg, offer free samples for testing, and maintain ready stock to ensure rapid shipment within 24 hours. We offer stable supply chain support and customized services—please feel free to contact us.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Reference:
[1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9017334/
[2]: https://www.nature.com/articles/s41598-020-70037-7
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8475422/
[4]: https://www.sciencedirect.com/science/article/abs/pii/S1558787815000568
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC12535861/
[6]: https://www.mdpi.com/2072-6643/17/9/1482
[7]: https://www.fda.gov/media/182086/download
[1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9017334/
[2]: https://www.nature.com/articles/s41598-020-70037-7
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8475422/
[4]: https://www.sciencedirect.com/science/article/abs/pii/S1558787815000568
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC12535861/
[6]: https://www.mdpi.com/2072-6643/17/9/1482
[7]: https://www.fda.gov/media/182086/download
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