Healthcare Supplement
Nicotinamide Riboside Chloride Powder
Kintainutri® Nicotinamide Riboside Chloride Manufacturers
Kintainutri® utilizes advanced enzyme catalysis combined with two-step column chromatography purification technology to professionally produce and supply high-purity nicotinamide ribochloride chloride powder. Our core product maintains a stable purity of over 99%. Key information is detailed in the table below:
NRCL powder is a derivative of vitamin B3 and the chloride salt form of nicotinamide ribose. Its structure consists of ribose bound to nicotinamide and it is naturally found in foods such as milk and meat. As a key precursor to the important intracellular coenzyme NAD+, it effectively increases NAD+ levels, activates proteins such as SIRT1 and SIRT3, thereby supporting cellular energy metabolism and mitochondrial health, and playing a positive role in maintaining metabolic homeostasis. Therefore, it is widely used in dietary supplements and other fields as a nutrient source to support cellular health and overall metabolism.
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Nicotinamide Riboside Chloride Production Process
Regulatory Status of Nicotinamide Riboside Chloride
● United States: It has received GRAS certification in the United States, and its tolerable daily intake (UL) is 180 mg/day for a 60 kg adult, while the limit for consumption as a dietary supplement is 300 mg/day.
●European Union: Nicotinamide riboside chloride has been recognized as a novel food by the EFSA. It is a bioavailable source of niacin and can be used in food supplements. For healthy adults (excluding pregnant and breastfeeding women), a daily intake of up to 300 mg is considered safe. For pregnant and breastfeeding women, a daily intake of up to 230 mg is considered safe.
●Australia: NR is permitted for use in foods for special medical purposes, with the content limited according to the rule that 1 mg of nicotinamide ribochloride = 0.42 mg of nicotinamide.
Nicotinamide Riboside Chloride Benefits
Nicotinamide Riboside Chloride Cancer
Nicotinamide riboside chloride, as a precursor to NAD⁺, has dual core value in cancer-related interventions, and neither of these values affects tumor control efficacy. On the one hand, it can preventively intervene in cancer cachexia (a characteristic muscle and fat wasting syndrome in advanced cancer). In the C26 adenocarcinoma mouse model, it can effectively alleviate weight loss and catabolic disorders by reducing the levels of inflammatory factors such as TNF-α and IL-6, inhibiting muscle atrophy-related ubiquitin ligases such as atrogin-1 and MuRF-1, and regulating metabolic pathways such as NAMPT and SIRT1, without promoting tumor growth.
On the other hand, it can protect neurons by activating SIRT2, prevent and alleviate peripheral neuropathy (CIPN) induced by cisplatin chemotherapy, without weakening the cytotoxicity of cisplatin to cancer cells such as lung cancer and head and neck squamous cell carcinoma, and may even enhance the chemotherapy sensitivity of some cancer cells, providing a potential solution for reducing side effects and improving the quality of life of patients in cancer treatment.
These values offer potential solutions for reducing the side effects of cancer treatment and improving patients' quality of life, and therefore can be used as an important direction for the development of cancer drug products.
What is nicotinamide riboside chloride used for?
Nicotinamide Riboside Chloride Supplement
As an effective precursor to NAD⁺, NR can be used as a supplement, which shows potential benefits for a variety of health problems related to metabolism and aging by increasing NAD⁺levels in the body.
Animal and some human studies have shown that it may improve insulin sensitivity, maintain liver health, and have beneficial effects on cardiovascular and neurodegenerative diseases. Meanwhile, in specific populations (such as patients with lower extremity peripheral artery disease), NR supplements have been shown to produce clinically meaningful improvements in exercise endurance by improving mitochondrial function and muscle health.
Nicotinamide Riboside Chloride Patches
Nicotinamide ribochloride chloride patches replenish skin NAD⁺ levels through transdermal absorption, with the core application being to improve skin health. They promote DNA repair, reduce oxidative damage and inflammation, thereby improving signs of photoaging (such as wrinkles and pigmentation), helping to strengthen the skin barrier and delay cellular aging. They are also suitable for the adjunctive prevention of precancerous skin lesions and are ideal for individuals seeking anti-aging and photodamage repair.
Is Nicotinamide Riboside Chloride Safe?
NRCL powder has received GRAS certification, and its safety is supported by animal experiments and human clinical trials. Short-term or long-term supplementation at daily doses up to 2 grams has not caused serious adverse reactions, and unlike niacin, it does not cause hot flashes. Only a few people experience mild discomfort, which can be relieved on its own.
It has no significant adverse effects on physiological indicators such as liver and kidney function, blood lipids, blood sugar, and blood pressure, and does not interfere with related metabolic processes. Nicotinamide riboside chloride has shown good tolerability in different populations, including healthy people, obese people, and the elderly, and is a highly safe NAD⁺precursor supplement.
Why Choose Nicotinamide Riboside Chloride Powder By Kintainutri®?
Kintainutri®, a leading company in the domestic plant extract industry, is committed to providing global customers with high-quality, high-purity nicotinamide riboside chloride powder raw materials. We have a GMP-compliant production base and, relying on solid R&D capabilities and a rigorous quality management system, maintain full control from raw materials to finished products, ensuring that every batch of products has excellent stability and reliability.
We employ advanced enzyme catalysis combined with a two-step column chromatography purification technique to precisely separate substrates, enzyme proteins, and other small molecule impurities, thereby ensuring that product purity remains consistently above 99% with extremely low impurity residue. This process not only guarantees high product purity and excellent consistency but also demonstrates outstanding performance in safety and bioavailability, providing a solid and reliable quality foundation for your end products.
By choosing us, you will receive:
✅High-purity, low-impurity NRCL raw materials;
✅Full-process services from technical support to stable supply.
We look forward to supporting your brand in gaining market trust and achieving sustainable growth through professional solutions and long-term, stable cooperation. Whether in the R&D stage or large-scale production, we are always your reliable partner.
You can obtain detailed nicotinamide riboside chloride bulk product quotations and documents by emailing natural@kintaibio.com!
*KINTAI Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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