Pharm Ingredients
Octacosanol Powder
What Is Octacosanol Powder?
Kintainutri® is dedicated to supplying high-purity, highly stable octacosanol powder to global brands in the dietary supplement, functional food, and sports nutrition sectors. We offer octacosanol powder in specifications ranging from 10% to 98%, ensuring consistent bioactivity and purity in every batch, making us the ideal raw material partner for your innovative formulations.
Octacosanol is a naturally occurring, highly saturated long-chain fatty alcohol widely found in plant-derived waxes, such as sugarcane wax, rice bran wax, and beeswax, as well as in wheat germ oil. It also serves as the core active ingredient of the functional raw material policosanol. Given its limited presence in the average diet, appropriate supplementation with octacosanol offers an effective way to improve metabolic health.
| Product Name | Source | Best-selling Specifications |
|---|---|---|
| Octacosanol Powder | Sugarcane | 50%, 60%, 90%, 95%, 98% |
| Rice Bran | 10%, 20%, 50%, 60%, 80%, 90% |
Scientific research has confirmed that octacosanol possesses multiple physiological regulatory functions, including lipid-lowering, antioxidant, anti-fatigue, anti-inflammatory, and hormone-regulating effects, and has an excellent safety profile, making it an ideal ingredient for dietary supplements and functional foods.
Octacosanol Powder Specification
| Item | Specification | Test Methods |
|---|---|---|
| Physical & Chemical Control | ||
| Appearance | White To Off-White Powder | Visual |
| Odor & Taste | Characteristic | Organoleptic |
| Loss on Drying | ≤5.0% | CP2020 |
| Residue on Ignition | ≤5.0% | CP2020 |
| Heavy Metals | ||
| Heavy Metals | NMT 10 ppm | CP2020 |
| Lead (Pb) | NMT 3 ppm | CP2020 |
| Arsenic (As) | NMT 2 ppm | CP2020 |
| Mercury (Hg) | NMT 0.1 ppm | CP2020 |
| Cadmium (Cd) | NMT 1 ppm | CP2020 |
| Microbiology Control | ||
| Total Plate Count | NMT 3,000 cfu/g | CP2020 |
| Total Yeast & Mold | NMT 300 cfu/g | CP2020 |
| E. coli | Negative | CP2020 |
| Salmonella | Negative | CP2020 |
| Packaging & Storage | ||
| Packaging | Paper-drum with two plastic bags inside, 25 kg/drum. Keep cool & dry, away from light & heat. | |
| Shelf Life | 2 years if sealed & stored properly. | |
1-Octacosanol Powder Extraction
Octacosanol Powder Benefits
Octacosanol benefits for men
Octacosanol ameliorates testicular and epididymal damage in a dose-dependent manner, significantly increasing sperm concentration and restoring fertility. It alleviates oxidative stress damage by scavenging excess ROS and MDA, promotes spermatocyte meiosis through the upregulation of cell cycle regulators such as CCNB1, CCNA2, and CDK1, and activates downstream spermatogenic signaling by restoring FSH, LH, and testosterone levels via the testosterone/androgen receptor axis.
Furthermore, it demonstrates a favorable safety profile, with no major organ toxicity observed at a dosage of 20 mg/kg. This ingredient serves as a key component for functional foods and dietary supplements aimed at male reproductive health, offering a natural, multi-target intervention strategy for individuals with oligospermia and infertility.
Policosanol benefits weight loss and cholesterol
Octacosanol combats diet-induced obesity by increasing energy expenditure in adipose tissue, improving hepatic lipid metabolism, and activating brown adipose tissue. Mixtures of long-chain fatty alcohols containing octacosanol (policosanol) can reduce adipose tissue mass and inhibit cholesterol biosynthesis, thereby collectively achieving weight control, a reduction in adipose tissue, and lowered serum TC and LDL-C levels.
Our product shows great promise for use in weight loss and as an adjunct intervention for obesity-related metabolic disorders, serving as an ingredient for functional foods and a key component of dietary supplements.
Policosanol for blood sugar
Octacosanol exerts a blood glucose-lowering effect by activating the AMPK pathway, thereby promoting skeletal muscle glucose uptake and inhibiting hepatic gluconeogenesis. It lowers fasting blood glucose levels and improves tissue insulin sensitivity; under hyperglycemic conditions, it stimulates an approximately 14% increase in insulin secretion, effectively aiding in blood glucose management. With a favorable safety profile, this ingredient can serve as a raw material for functional foods designed to support diabetes management.
Policosanol for high blood pressure
Octacosanol can significantly lower both systolic and diastolic blood pressure; this effect is associated with the inhibition of LDL oxidation and the alleviation of oxidative stress-induced damage to the vascular endothelium. Additionally, it improves vascular function by increasing levels of prostacyclin (a vasodilator) and decreasing levels of thromboxane A₂ (a vasoconstrictor). Kintainutri®’s octacosanol powder demonstrates a favorable safety profile and serves as a natural ingredient for supporting blood pressure management in functional foods and dietary supplements.
What Is Octacosanol Powder Used For?
Octacosanol powder is widely used in the development of products such as octacosanol supplements and policosanol capsules. In the sports nutrition sector, it serves as a key active ingredient in international sports supplements; it significantly boosts endurance, energy, and physical stamina while alleviating post-exercise muscle soreness, making it an ideal choice for formulators developing anti-fatigue and energy-replenishing products.
In the field of cardiovascular health, it is widely marketed internationally, often in the form of policosanol capsules, for supporting cardiovascular health in middle-aged and older adults. Clinical studies have demonstrated its efficacy in lowering cholesterol, improving blood lipid profiles, and supporting myocardial function. Characterized by a high safety profile, this ingredient is suitable for use in functional foods and dietary supplements.
Octacosanol Powder Dosage
Octacosanol effectively improves the lipid profile at a daily dosage of 10–20 mg, reducing LDL-C by 18–26% and total cholesterol by 13–17%, while increasing HDL-C by 15–28%. Notably, 10 mg of octacosanol achieves a lipid-lowering magnitude comparable to that of 20 mg of lovastatin. However, as it does not directly inhibit HMG-CoA reductase, it avoids the common side effects associated with statins, thereby offering superior safety and compliance advantages for long-term intervention and functional food applications.
Octacosanol Powder Side Effects
Based on a synthesis of clinical studies, systematic reviews, and safety assessments, octacosanol (policosanol) is generally well-tolerated, with an incidence of adverse reactions comparable to that of a placebo. Common side effects, including headache, dizziness, insomnia, gastrointestinal discomfort, skin rash, and muscle cramps, are generally mild and transient, typically requiring no specific intervention. Regarding laboratory parameters, no clinically significant abnormalities were observed in liver or kidney function, blood glucose levels, or complete blood counts. Long-term use (up to three years) demonstrated a favorable safety profile, with no serious adverse reactions reported.
Notably, octacosanol exhibits anti-platelet aggregation activity; therefore, caution and monitoring are advised when it is co-administered with anticoagulants (such as warfarin). Conversely, co-administration with statins may mitigate the latter's hepatotoxicity. Overall, N-Octacosanol is considered safe for use as a functional food ingredient.
Where To Buy Octacosanol Powder?
As a leading octacosanol supplier, Kintainutri® leverages a robust supply chain and advanced extraction technology to provide a stable, long-term supply of high-purity octacosanol powders in specifications ranging from 10% to 98%. Our products meet export standards for Europe and the US; processed via all-physical supercritical extraction, they guarantee zero solvent residue and high biological activity.
Whether you are a formulator or procurement manager specializing in sports nutrition, cardiovascular health, or functional foods, we offer customized ingredient solutions tailored to your needs. Please contact us today for detailed information and highly competitive pricing.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
FAQ
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Is octacosanol powder a type of alcohol?
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Does policosanol remove plaque from arteries?
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