Cosmetic Ingredients
Paeonia Suffruticosa Root Extract Powder
Paeonia Suffruticosa Root Extract Powder Supplier
Kintainutri®’s paeonia suffruticosa root extract is made from the dried roots of white peony, a plant in the Ranunculaceae family, which are free of pesticide residues. It is prepared using advanced ultrasonic extraction technology. We mainly supply customers around the world with 98% albiflorin and 10%-98% paeoniflorin powder content.
Here are our main best-selling specifications:
Here are our main best-selling specifications:
Paeoniflorin, the main active ingredient in the dried root of Paeonia lactiflora, belongs to the class of natural monoterpenoid glycosides.
It possesses a variety of pharmacological effects, including anti-inflammatory, antioxidant, neurotransmitter-regulating, immunomodulatory, analgesic, antitumor, hypoglycemic, antidepressant, hepatoprotective, and anti-ulcer properties.
It is widely used in cosmetics and pharmaceuticals and is an important candidate compound for treating pain, inflammation, and related chronic diseases.
It possesses a variety of pharmacological effects, including anti-inflammatory, antioxidant, neurotransmitter-regulating, immunomodulatory, analgesic, antitumor, hypoglycemic, antidepressant, hepatoprotective, and anti-ulcer properties.
It is widely used in cosmetics and pharmaceuticals and is an important candidate compound for treating pain, inflammation, and related chronic diseases.
Paeonia Suffruticosa Root Extract Extraction Source Advantages
1.High-quality white peony producing areas
Our raw materials are sourced from Heze, Shandong, the core producing area of Chinese white peony. This region boasts over two thousand years of white peony cultivation history and is known as the "Hometown of Chinese White Peony," serving as a core distribution center for high-quality white peony in northern China.
Heze boasts a mild climate and fertile soil, providing ideal natural conditions for the growth of white peony, resulting in raw materials with abundant nutrients and superior quality. We directly connect with local standardized planting bases to control quality from the source, eliminating intermediate links and maximizing the freshness and quality stability of the raw materials.
2.Natural and safe paeonia albiflora root
Our partner peony plantation strictly adheres to the GAP standardized planting system, using organic fertilizers throughout the entire process from planting to harvesting, and eliminating highly toxic pesticides to ensure the naturalness and safety of the raw materials from the source. This standardized management system ensures that our products fully comply with international market access standards, providing customers with a truly worry-free choice.
3.High-quality active ingredients
High-quality, locally sourced raw materials ensure a naturally high content of the core active ingredients—paeoniflorin powder and albiflorin. This not only provides a solid foundation for subsequent extraction but also guarantees the stability and traceability of the efficacy components in our final product.
Specification of Paeonia Suffruticosa Root Extract Powder
| Item | Specifications | Results |
|---|---|---|
| Appearance | Light Brown Powder | Conforms |
| Assay | Paeoniflorin≥10.0% | 10.38% |
| Particle Size | ≥95% through 80 mesh | Conforms |
| Residue on Ignition | ≤5g/100g | 3.52g/100g |
| Loss on Drying | ≤5g/100g | 3.05g/100g |
| Identification | Conforms with TLC | Conforms |
| Residue Analysis | ||
| Heavy Metals | ≤10 ppm | Conforms |
| Lead (Pb) | ≤3.0 ppm | Conforms |
| Mercury (Hg) | ≤0.5 ppm | Conforms |
| Cadmium (Cd) | ≤1.0 ppm | Conforms |
| Arsenic (As) | ≤2.0 ppm | Conforms |
| Microbiological Tests | ||
| Total plate count(cfu/g) | ≤1000 cfu/g | 200 cfu/g |
| Yeast & Mold count(cfu/g) | ≤100 cfu/g | 10 cfu/g |
| E.coli | Negative/10g | Conforms |
| Salmonella | Negative/10g | Conforms |
| S.aureus | Negative/10g | Conforms |
| Conclusion | Confirm to Specification and Standards. | |
How to Make Peony Extract Paeonia Suffruticosa Root Extract Powder?
Kintainutri® uses advanced ultrasonic extraction to extract 98% paeoniflorin powder from high-quality white peony root.
Paeonia Suffruticosa Root Extract Benefits
Paeonia Suffruticosa Root Extract Paeoniflorin For Analgesic
White peony root extract paeoniflorin can inhibit the release of pro-inflammatory factors and regulate multiple pain-related signaling pathways, thereby effectively relieving various types of pain, including inflammatory pain, neuropathic pain, cancer pain, spasmodic pain, and psychogenic pain.
Furthermore, it can activate adenosine A1 receptors and inhibit the release of excitatory neurotransmitters, further enhancing the analgesic effect. Overall, paeoniflorin possesses multi-target, multi-pathway, and low-toxicity characteristics, so you can confidently use our paeoniflorin in the development of non-opioid analgesic drugs.
Paeonia Suffruticosa Root Extract Paeoniflorin For Depression
Existing research indicates that paeoniflorin extract exerts its antidepressant effects through multiple targets and pathways. It can regulate the hyperfunction of the hypothalamus-pituitary-adrenal axis, restore normal endocrine stress response, increase the level of monoamine neurotransmitters, inhibit neuroinflammation, maintain calcium ion homeostasis, improve mitochondrial function, and regulate autophagy. Furthermore, it can promote neuroplasticity by increasing the expression of brain-derived neurotrophic factor.
In addition, classic Chinese medicine formulas containing paeoniflorin powder(such as Xiaoyao San and Chaihu Shugan San) have shown significant antidepressant effects in clinical and animal experiments, indicating that they have good prospects for antidepressant application and high safety, and can be used to develop drugs for the treatment of depression.
Image & Reference: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1614429/full.
Paeonia Suffruticosa Root Extract Albiflorin For liver fibrosis
Paeonia lactiflora root extract paeoniflorin significantly improves thioacetamide-induced liver fibrosis by regulating the NURR1-mediated inflammatory signaling pathway.
Its mechanism of action mainly involves: activating NURR1 expression, inhibiting P2×7r-mediated NLRP3 inflammasome activation, and reducing the release of pro-inflammatory factors such as IL-1β and IL-23; simultaneously inhibiting the activation of hepatic stellate cells and epithelial-mesenchymal transition, reducing the deposition of extracellular matrix components such as collagen I and α-SMA, and regulating the TIMP-1/MMP-13 balance to promote matrix degradation.
Furthermore, paeoniflorin can also regulate the inflammatory dialogue between macrophages and hepatic stellate cells, reducing the infiltration of inflammatory cells in the liver, thus exerting a synergistic anti-hepatic fibrosis effect through multiple pathways.
Its mechanism of action mainly involves: activating NURR1 expression, inhibiting P2×7r-mediated NLRP3 inflammasome activation, and reducing the release of pro-inflammatory factors such as IL-1β and IL-23; simultaneously inhibiting the activation of hepatic stellate cells and epithelial-mesenchymal transition, reducing the deposition of extracellular matrix components such as collagen I and α-SMA, and regulating the TIMP-1/MMP-13 balance to promote matrix degradation.
Furthermore, paeoniflorin can also regulate the inflammatory dialogue between macrophages and hepatic stellate cells, reducing the infiltration of inflammatory cells in the liver, thus exerting a synergistic anti-hepatic fibrosis effect through multiple pathways.
Reference: https://pubmed.ncbi.nlm.nih.gov/38626607/.
Is Paeonia Suffruticosa Root Extract safe?
Safety of Paeonia Suffruticosa Root Extract Paeoniflorin Powder
Studies have shown that paeoniflorin powder has a generally good safety profile.
Firstly, acute toxicity tests showed a high oral median lethal dose (LD50) (14.55 g/kg in rats), indicating a wide safety margin. Further subacute and chronic toxicity studies also confirmed good tolerability with long-term use at therapeutic doses (100-400 mg/kg), without significant toxicity to major organs such as the liver and kidneys.
Simultaneously, genotoxicity and mutagenicity tests were negative, indicating no risk of genotoxicity. Furthermore, safety pharmacology studies have confirmed that paeoniflorin has no significant adverse effects on the cardiovascular, respiratory, or central nervous systems.
Firstly, acute toxicity tests showed a high oral median lethal dose (LD50) (14.55 g/kg in rats), indicating a wide safety margin. Further subacute and chronic toxicity studies also confirmed good tolerability with long-term use at therapeutic doses (100-400 mg/kg), without significant toxicity to major organs such as the liver and kidneys.
Simultaneously, genotoxicity and mutagenicity tests were negative, indicating no risk of genotoxicity. Furthermore, safety pharmacology studies have confirmed that paeoniflorin has no significant adverse effects on the cardiovascular, respiratory, or central nervous systems.
Safety of Paeonia Suffruticosa Root Extract Albiflorin
Paeoniflorin lactone has a good safety profile in both in vivo and in vitro models.
In animal studies, no significant toxicity was observed at conventional oral or intraperitoneal doses (e.g., 5–200 mg/kg), and acute toxicity studies showed that doses up to 5000 mg/kg did not produce any observable toxic effects.
In animal studies, no significant toxicity was observed at conventional oral or intraperitoneal doses (e.g., 5–200 mg/kg), and acute toxicity studies showed that doses up to 5000 mg/kg did not produce any observable toxic effects.
In cell experiments, concentrations of 1–100 μM showed no significant cytotoxicity to various cell lines (such as PC12 cells), with cell viability remaining above 90%. Furthermore, chromosomal aberration, bone marrow micronucleus assay, and metabolomics analysis were all negative, indicating no significant genotoxicity or metabolic toxicity.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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