Pharm Ingredients
Senna Leaf Extract Sennosides Powder
Kintainutri®—Senna Leaf Extract Sennosides Powder Factory
Kintainutri®’s senna leaf extract powder is produced through the extraction of sennosides from senna leaves using a traditional ethanol solvent. The product’s primary active component, standardized sennosides, is verified by HPLC and can be customized to a content range of 8% to 40%.
The following are the best-selling specifications of Senna Leaf Extract Powder:
The following are the best-selling specifications of Senna Leaf Extract Powder:
Sennosides are natural anthraquinone glycosides extracted from the dried leaves of cassia angustifolia. They are a highly effective stimulant laxative, typically appearing as a brown powder. They effectively relieve constipation by stimulating intestinal peristalsis.
As a milder, more natural laxative than chemical drugs, they are widely used in various constipation treatments and intestinal health products.
As a milder, more natural laxative than chemical drugs, they are widely used in various constipation treatments and intestinal health products.
Kintainutri®’s Senna Leaf Extract Sennosides Characteristics
1. Excellent water solubility (500mg of the product dissolves in 150ml of room temperature water, resulting in a clear, impurity-free solution).
2. Not prone to clumping (the process uses adsorption resin to remove polysaccharides, chlorophyll and other moisture-absorbing components).
3. The strong herbal taste is removed through the adsorption process, resulting in a pleasant taste.
Specification of Senna Leaf Extract Sennosides Powder
| Item | Specifications | Results |
|---|---|---|
| Appearance | Brown powder | Conforms |
| Assay | Sennosides≥20.0% | 20.95% |
| Particle Size | ≥95 through 80 mesh | Conforms |
| Bulk density | 0.30-0.80g/ml | Conforms |
| Ash | ≤5% | 3.43% |
| Loss on Drying | ≤6% | 2.96% |
| Residue Analysis | ||
| Heavy Metals | ≤10 ppm | Conforms |
| Pb | ≤2.0 ppm | Conforms |
| Hg | ≤1.0 ppm | Conforms |
| Cd | ≤0.5 ppm | Conforms |
| As | ≤2.0 ppm | Conforms |
| Microbiological Tests | ||
| Total plate count(cfu/g) | ≤1000 cfu/g | Conforms |
| Yeast & Mold count(cfu/g) | ≤100 cfu/g | Conforms |
| E.coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion | Confirm to Specification and Standards. | |
Senna Leaf Extract Sennosides Powder Production Process
Kintainutri® produces senna leaf extract powder, which is obtained from the leaves of the senna plant (a legume) through extraction, concentration, purification, extraction, and spray drying.
The specific process flow is as follows:
The specific process flow is as follows:
Senna Leaf Extract Sennosides Benefits
Senna Leaf Extract Sennosides For Constipation
Sennoside, a natural dianthrone glycoside extracted from senna leaves, primarily exerts its laxative effect by being converted into the active metabolite rhein anthrone by intestinal flora in the colon.
Its mechanisms include inhibiting proximal colonic contractions to accelerate intestinal contents transport and reduce water absorption, and activating colonic macrophages to secrete prostaglandin E2, downregulating the expression of aquaporin AQP3, thereby inhibiting water transport from the intestinal lumen to the bloodstream and ultimately promoting defecation.
Furthermore, sennoside powder can also regulate the expression of various aquaporins, enhancing intestinal water retention and further improving constipation symptoms.
Its mechanisms include inhibiting proximal colonic contractions to accelerate intestinal contents transport and reduce water absorption, and activating colonic macrophages to secrete prostaglandin E2, downregulating the expression of aquaporin AQP3, thereby inhibiting water transport from the intestinal lumen to the bloodstream and ultimately promoting defecation.
Furthermore, sennoside powder can also regulate the expression of various aquaporins, enhancing intestinal water retention and further improving constipation symptoms.
Reference: https://onlinelibrary.wiley.com/doi/epdf/10.1111/ics.13055; https://www.mdpi.com/2223-7747/11/23/3379.
What is Senna Leaf Extract Sennosides Used For?
Currently, with people paying increasing attention to health management and natural raw materials, senna leaf extract is widely used in functional foods, beverages and dietary supplements for relieving constipation, promoting intestinal health and detoxification. It has a broad market demand, especially in the form of capsules and tablets for constipation relief and intestinal health products, herbal teas and weight loss products.
Are sennosides safe?
Sennosides powder exhibits good safety at normal doses. Multiple toxicological studies have shown that sennoside A did not show genotoxicity in in vitro microorganisms and mammalian cells, and its LD50 in rodents (rats and mice) is approximately 5000 mg/kg. No significant adverse effects were observed in reproductive toxicity, embryonic development, or offspring growth.
Short-term use results in mild adverse reactions, commonly mild gastrointestinal irritation, and most symptoms resolve spontaneously upon discontinuation. Long-term, high-dose use of sennoside A may induce melanosis coli, increase the imbalance between cell proliferation and apoptosis, trigger inflammatory cell infiltration, and induce abnormal crypt formation, potentially increasing the risk of colorectal cancer.
Although conclusive evidence currently lacks evidence that sennoside A directly causes tumorigenesis, its intestinal metabolites (such as rhein anthrone) may be key factors contributing to the aforementioned toxic side effects. Therefore, the dosage and duration of use of sennoside A should be strictly controlled in clinical practice to avoid long-term abuse.
Short-term use results in mild adverse reactions, commonly mild gastrointestinal irritation, and most symptoms resolve spontaneously upon discontinuation. Long-term, high-dose use of sennoside A may induce melanosis coli, increase the imbalance between cell proliferation and apoptosis, trigger inflammatory cell infiltration, and induce abnormal crypt formation, potentially increasing the risk of colorectal cancer.
Although conclusive evidence currently lacks evidence that sennoside A directly causes tumorigenesis, its intestinal metabolites (such as rhein anthrone) may be key factors contributing to the aforementioned toxic side effects. Therefore, the dosage and duration of use of sennoside A should be strictly controlled in clinical practice to avoid long-term abuse.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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