Pharm Ingredients
Vitamin B2 Riboflavin Powder
Vitamin B2 Riboflavin Powder Manufacturers
What Is Vitamin B2?
Kintainutri® high-purity Riboflavin (Vitamin B2) powder is refined from premium raw materials. It features a purity level of ≥98% and complies with USP standards, offering a fine particle size and excellent flowability. Riboflavin is an essential water-soluble B-vitamin that occurs naturally in foods such as animal liver, eggs, dairy products, and leafy green vegetables.
As a precursor to two essential coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), it plays a vital role in key physiological processes, including energy metabolism, cell growth, and antioxidant defense. Kintainutri® vitamin b2 riboflavin powder is suitable for a wide range of applications, including dietary supplements, functional foods, feed premixes, and pharmaceutical formulations, delivering consistent and reliable quality to customers worldwide.
Riboflavin Vitamin B2 Sources
Vitamin B2 (riboflavin) is widely found in animal-based foods, such as liver, kidney, lean meat, eggs, and dairy products, as well as plant-based sources, including spinach, almonds, quinoa, shiitake mushrooms, and whole grains. In addition, many fortified breakfast cereals are significant dietary sources of riboflavin. However, given the limited riboflavin content in natural foods, its susceptibility to degradation by light, and the fact that riboflavin in plant-based ingredients requires hydrolysis for absorption, supplementation via dietary supplements and feed additives is a reliable method to ensure adequate intake.
Vitamin B2 Riboflavin Powder Specification
| ANALYSIS | SPECIFICATION | METHOD | |
|---|---|---|---|
| ASSAY & IDENTIFICATION | |||
| Assay | 99% | UV / USP<201> | |
| Identification | Correspond to standard | TLC / USP<201> | |
| PHYSICAL CHARACTERISTICS | |||
| Particle Size | NLT 95% Through 80 mesh | Analytical sieving / USP | |
| Loss on Drying | NMT 5.00% | USP | |
| Total Ash | NMT 5.00% | USP | |
| Bulk Density | Between 40-60g/100ml | USP | |
| CHEMICAL CHARACTERISTICS | |||
| Residual Solvent | NMT 5000ppm | GC / USP | |
| Pesticide Residue | Meet the requirements | GC / USP | |
| Heavy Metals (as Pb) | NMT 10ppm | USP Method II | |
| Arsenic (As) | NMT 2ppm | ICP-MS | |
| Lead (Pb) | NMT 2ppm | ICP-MS | |
| Cadmium (Cd) | NMT 1ppm | ICP-MS | |
| Mercury (Hg) | NMT 1ppm | ICP-MS | |
| MICROBIOLOGICAL CHARACTERISTICS | |||
| Total Plate Count | NMT 10000cfu/g | USP | |
| Total Yeast & Mold | NMT 1000cfu/g | USP | |
| E.Coli | Not Detected in (g) 10 | USP | |
| Salmonella | Not Detected in (g) 25 | USP | |
| Staphylococcus | Not Detected in (g) 10 | USP | |
How To Make Vitamin B2 Riboflavin Powder?
Vitamin B2 Riboflavin Powder Benefits
Vitamin B2 Riboflavin Migraine
Vitamin B2 is a precursor to flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), both of which play pivotal roles in the mitochondrial electron transport chain and energy production. A decline in mitochondrial energy reserves in the brain may activate the trigeminovascular system, contributing to migraine attacks. Research on vitamin B2 and migraine suggests that riboflavin supplementation may help prevent migraines by supporting mitochondrial function, enhancing the activity of mitochondrial complexes I and II, improving electron transport, and increasing FAD and FMN availability.
Riboflavin may also exert anti-inflammatory and antinociceptive effects. High-dose riboflavin (400 mg/day) has been recommended as a migraine prevention strategy by the American Academy of Neurology and the Canadian Headache Society, making it a well-established ingredient for functional food and dietary supplement brands developing products for vitamin B2 for headache and migraine support.
Riboflavin Pregnancy
Vitamin B2 (riboflavin) may support female reproductive health through two complementary mechanisms: ① Antioxidant activity: riboflavin is phosphorylated to form FMN and FAD, which serve as coenzymes for redox enzymes such as glutathione reductase, helping to mitigate oxidative stress-related damage to the ovaries and endometrium. Oxidative stress has been associated with reproductive conditions such as endometriosis and polycystic ovary syndrome (PCOS). ② Anti-inflammatory activity: riboflavin may help reduce plasma levels of inflammatory factors such as IL-6 and TNF-α, potentially mitigating the effects of inflammation and reproductive tract infections on fertility.
Riboflavin pregnancy nutrition is also relevant because adequate riboflavin intake supports maternal nutritional needs during pregnancy.Kintainutri® Vitamin B2 Powder offers a high safety profile and is suitable for development into functional foods and dietary supplements for preconception nutritional support and female reproductive health. It can serve as a core or complementary ingredient in prenatal multivitamin tablets, fertility support formulas, and functional milk powders.
Vitamin B2 For Chickens
As a key precursor to FMN and FAD, vitamin B2 (riboflavin) plays a vital role in mitochondrial energy metabolism and redox reactions in poultry, earning it the reputation of a "growth-promoting vitamin." Vitamin B2 for chickens supports efficient feed utilization by facilitating the metabolism of carbohydrates, fats, and proteins. It also acts as a coenzyme for glutathione reductase, helping protect cells against oxidative stress, while supporting proper protein folding and nervous system function.
Dietary riboflavin supplementation significantly improves weight gain and the feed-to-gain ratio in meat poultry, boosts egg production, hatchability, and chick vitality in breeder flocks, and reduces the incidence of leg disorders and curled-toe paralysis, all while maintaining an excellent safety profile. As a core B-vitamin component in feed premixes, riboflavin effectively supports high-intensity production performance and minimizes farming losses, making it suitable for inclusion in diets across all growth stages.
What Is Vitamin B2 Riboflavin Powder Used For?
Vitamin B2 Supplement
Riboflavin powder is widely used in various dietary supplements, including vitamin B2 supplements. Common multivitamin-mineral formulations typically provide 1.3 mg of riboflavin per serving, meeting 100% of the recommended daily intake. Single-ingredient riboflavin products and B-complex formulas are also widely available on the market, including convenient formats such as vitamin B2 gummies.
Most products utilize free-form riboflavin, while some employ riboflavin 5'-phosphate. As an essential nutrient involved in mitochondrial energy metabolism and antioxidant defense, riboflavin may support neurological health and help prevent migraines, with different forms and delivery formats available to meet diverse formulation needs.
Vitamin B2 Riboflavin Tablets
Riboflavin powder is widely used in the field of pharmaceutical raw materials. As an active pharmaceutical ingredient (API), it is incorporated into standard oral formulations, including Vitamin B2 Riboflavin Tablets and Vitamin B2 Pills, which are used to prevent and treat riboflavin deficiency and related conditions, such as angular cheilitis. Highly water-soluble riboflavin sodium phosphate is also utilized in specialized pharmaceutical preparations, including injections and eye drops. Clinically, high-dose riboflavin (400 mg/day) is commonly used for migraine prevention. It is also an important treatment for riboflavin transporter deficiency, a rare neurological disorder, and may serve as an adjunctive therapy for conditions associated with mitochondrial dysfunction.
Feed Additives
Regarding growth performance, dietary riboflavin supplementation can significantly improve weight gain and feed conversion efficiency in poultry, including broilers, turkeys, and ducks, while reducing mortality and the incidence of skeletal abnormalities, such as leg disorders and curled-toe paralysis. In terms of reproductive performance, riboflavin plays a crucial role in egg production rate, egg weight, hatchability, and chick vitality. Riboflavin deficiency can increase embryonic mortality and contribute to abnormal down development, such as “clubbed down.”
As a key B-vitamin component in feed premixes, riboflavin offers high safety and cost-effectiveness, making it an ideal solution for feed additive companies, premix manufacturers, and large-scale poultry farming groups, suitable for inclusion in poultry diets across all growth stages.
Vitamin B2 Riboflavin Powder Deficiency Diseases
The risk of vitamin b2 riboflavin powder deficiency is higher among the following four groups of people:
● Vegetarian athletes: Physical activity may increase the body's demand for riboflavin. Because vegetarians often consume fewer animal-based foods that are rich in riboflavin, such as dairy products, eggs, and meat, vegetarian athletes may face an increased risk of inadequate riboflavin intake.
● Pregnant and lactating women: Fetal development and milk production increase the body's demand for riboflavin. Inadequate riboflavin intake during pregnancy, particularly below the recommended intake of 1.2 mg/day, has been associated with potential risks such as low birth weight and cardiac outflow tract defects and may also be associated with an increased risk of preeclampsia.
● Strict vegetarians and individuals with low dairy intake: Meat and dairy products are important dietary sources of riboflavin. Consequently, individuals who strictly avoid animal-based foods or consume little dairy may be at increased risk of inadequate riboflavin intake, regardless of whether they live in developing or developed countries.
● Patients with riboflavin transporter deficiency: Caused by genetic mutations, riboflavin transporter deficiency impairs the body's ability to properly transport and utilize riboflavin. Although it is a rare disorder, high-dose riboflavin supplementation is an important treatment option and may substantially improve clinical outcomes.
Vitamin B2 Riboflavin Powder Dosage
| Subject | Category | Riboflavin Recommended Dosage |
| Human | Adult male | 1.3 mg/day |
| Adult female | 1.1 mg/day | |
| Pregnant women | 1.4 mg/day | |
| Lactating women | 1.6 mg/day | |
| Children & adolescents | Gradually increase from 0.3 mg to adult‑level intake | |
| Poultry (Feed addition) |
Broiler chicken | 3.6‑9.0 mg/kg feed |
| Laying hen | 2.5‑6.6 mg/kg feed | |
| Breeding hen | 7.0‑16.0 mg/kg feed |
The recommended intake of vitamin b2 riboflavin powder varies depending on the population and intended use. Notably, vitamin B2 has an excellent safety profile; no tolerable upper intake level has been established, and no adverse reactions have been reported even with high-dose supplementation (such as 400 mg daily in humans for three months or levels far exceeding requirements in poultry), allowing it to safely meet the additional metabolic demands associated with specific physiological stages and high-intensity production.
Vitamin B2 Riboflavin Powder Side Effects
Riboflavin has an excellent overall safety profile, and no Tolerable Upper Intake Level (UL) has been established. A small number of users may experience mild gastrointestinal symptoms, such as nausea, diarrhea, or abdominal pain, as well as polyuria, drowsiness, or dizziness. These effects are generally transient and do not require specific intervention. Some children may experience vomiting or increased appetite. The most frequently observed effect is bright yellow urine, which is a normal result of the excretion of water-soluble riboflavin metabolites and is completely harmless. Overall, riboflavin is extremely well-tolerated; no serious adverse reactions have been reported, even with long-term use at high daily doses of 400 mg.
Where To Buy Vitamin B2 Riboflavin Powder?
Kintainutri® high-purity vitamin b2 riboflavin powder meets the diverse needs of pharmaceutical, food, and feed applications with a purity exceeding 99% and consistent batch-to-batch quality. Backed by rigorous quality control and a stable, long-term supply chain, we are dedicated to providing safe and reliable nutritional solutions to global customers. Available in various specifications, our product ensures consistent quality and is suitable for the development of multivitamin and B-complex formulations. We offer samples and technical support; please feel free to contact us for inquiries.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
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