Pharm Ingredients
PQQ Pyrroloquinoline Quinone Powder
Kintainutri® PQQ Pyrroloquinoline Quinone Powder Factory
Kintainutri, a leading Pyrroloquinoline Quinone Powder supplier in China, boasts over ten years of extraction experience and technology. We utilize a bio-fermentation process to produce PQQ powder with a purity of up to 99% and stable composition, certified by HPLC. Specific information on Pyrroloquinoline Quinone Disodium Salt is as follows:
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PQQ Pyrroloquinoline quinone is an important vitamin-like substance and novel coenzyme with powerful antioxidant, anti-inflammatory, and mitochondrial protective effects. It shows potential in treating heart and neurological diseases and promoting cell growth, and is widely used in pharmaceuticals, dietary supplements, and functional food ingredients.
PQQ Pyrroloquinoline Quinone COA
How to make PQQ powder?
Regulatory Status of PQQ Pyrroloquinoline Quinone Powder
● China: Approved as a new food ingredient in 2022, with a daily intake of ≤20 mg for adults. Its production process is chemical synthesis, and it can be applied in the beverage industry. Its safety for consumption has been recognized.
● United States: PQQ has obtained GRAS certification from the U.S. FDA and can be used as an ingredient in energy drinks, sports drinks, electrolyte drinks and bottled water. In 2009, the United States approved the first PQQ dietary supplement. Since PQQ is slightly soluble in water, the supplement is made of PQQ sodium salt (PQQ-2Na+).
● European Union: On August 13, 2018, the ESFA issued Regulation (EU) 2018/1122, approving pyrroloquinoline quinone sodium salt as a novel food, allowing it to be used as a dietary supplement as defined in Directive 2002/46/EC, targeting adults but excluding pregnant and lactating women, with a maximum daily dose of 20 mg.
● Canada: In 2012, Health Canada approved PQQ as a natural health food.
● Japan: In 2013, the Japanese Ministry of Health, MHLW classified PQQ as a non-drug in the food and drug classification.
Reference:
https://cisema.com/en/32-food-ingredients-food-additives-and-food-related-products-officially-approved-in-china/；
https://www.fda.gov/files/food/published/GRAS-Notice-000709--Pyrroloquinoline-quinone-disodium-salt.pdf；
https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2017.5058;
https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2017.5058;
https://health-products.canada.ca/lnhpd-bdpsnh/info?licence=80071357；
https://www.mgc.co.jp/eng/corporate/news/files/130918_e%20%281%29.pdf.
PQQ Pyrroloquinoline Quinone Health Benefits
Studies have shown that PQQ has a variety of physiological functions, which can protect cells from damage caused by oxidative stress and provide comprehensive protection at the cellular level. It can also effectively maintain neurological and cardiovascular health, promote growth and proliferation, and show clear positive effects in several key health areas such as supporting heart function, reproductive health, weight management and skin condition improvement.
PQQ Pyrroloquinoline Quinone For Skin
Studies have shown that pyrroloquinoline quinone PQQ possesses highly efficient antioxidant capabilities, scavenging free radicals, protecting vitamin E, reducing skin oxidative stress and DNA damage, and simultaneously promoting mitochondrial generation and functional optimization by activating related pathways, thereby enhancing skin cell energy metabolism efficiency and repair capabilities. It can also inhibit the expression of inflammatory factors and related inflammatory pathways, reduce skin inflammation and protect the skin barrier.
Furthermore, it can regulate the balance of gut microbiota and enhance the integrity of the gut barrier, indirectly reducing the risk of skin inflammation and allergies through the gut-skin axis, and improving skin problems caused by dysbiosis. In addition, it can inhibit cell aging, promote skin cell proliferation, and reduce the expression of matrix metalloproteinases to reduce collagen degradation, thereby improving signs of aging such as thinning skin, sparse hair follicles, and disordered collagen fibers, helping the skin maintain a healthy and youthful state.
PQQ Pyrroloquinoline Quinone For Weight Loss
Methoxatin Disodium Salt has clear potential in weight management and reducing fat accumulation, and its mechanism of action is well-established and supported by multiple animal experiments and in vitro studies. PQQ reduces adipocyte differentiation and lipid accumulation by activating the LKB1/AMPK pathway and inhibiting the expression of adipogenesis-related genes and the activity of key factors such as ACC and SREBP-1.
Simultaneously, it upregulates PGC-1α expression, promotes mitochondrial biogenesis and fatty acid oxidation, enhances the body's energy metabolism efficiency, and drives the conversion of white adipose tissue into thermogenic brown adipose tissue, further increasing energy expenditure. Furthermore, PQQ, with its antioxidant and anti-inflammatory properties, can alleviate obesity-related inflammation and oxidative stress, improve insulin sensitivity, blood glucose and cholesterol levels, reduce abdominal visceral fat accumulation, and has a protective effect on skeletal muscle without affecting normal physiological functions.
Choosing PQQ powder from our factory can provide solid support for your product development, helping you create differentiated and competitive weight loss solutions. We aspire to be your reliable and long-term trustworthy raw material partner, working together to build product advantages in the functional food and dietary supplement markets.
Reference: https://www.mdpi.com/2076-3921/13/9/1027；
PQQ for Heart Health
Pyrroloquinoline quinone (PQQ) has multidimensional and well-defined protective effects on heart health. In diabetic cardiomyopathy (DCM), it reduces oxidative stress and myocardial fibrosis by inhibiting NF-κB/NLRP3 inflammasome-mediated pyroptosis, enhancing antioxidant enzyme activity, and promoting cardiovascular health.
In drug-induced cardiotoxicity (such as doxorubicin), it synergistically regulates the Nrf2 and NF-κB signaling pathways, reducing myocardial injury markers. For stress-induced myocardial hypertrophy and fibrosis, it reduces lipid peroxidation and improves mitochondrial function by regulating YAP protein and upregulating anti-ferroptosis protein.
Furthermore, it can activate the SIRT1/PGC-1α pathway to promote mitochondrial biogenesis, alleviate ischemia-reperfusion injury, and moderately uncouple ROS levels. These effects work synergistically to reduce myocardial injury markers and improve cardiac function, providing potential strategic support for maintaining heart health and preventing heart failure. They are a reliable raw material choice for developing heart health pharmaceuticals and health products.
Pyrroloquinoline Quinone For Fertility
As a highly active water-soluble antioxidant, pyrroloquinoline quinone (PQQ) has a singlet oxygen quenching capacity approximately 6.3 times that of vitamin C, and its potential for multifaceted protection and promotion in reproductive health has been fully demonstrated by animal studies.
PQQ can effectively counteract the damage to the ovaries caused by alkylating agents such as cyclophosphamide and busulfan. Its core mechanism is to promote the proliferation of ovarian granulosa cells, inhibit cell apoptosis and senescence, thereby reducing the loss of follicles at each stage and lowering the proportion of degenerated follicles. At the same time, PQQ helps regulate key hormone levels, such as increasing the ovarian reserve marker AMH, decreasing FSH and restoring E2, and improving disordered estrous cycles.
In addition, its anti-inflammatory properties (downregulating IL-1α and IL-1β), antioxidant stress (reducing MDA and 8-OHdG), and mitochondrial biogenesis-promoting properties (upregulating PGC1α expression) can comprehensively optimize the ovarian microenvironment, providing multi-dimensional scientific support for the protection and promotion of fertility.
PQQ Pyrroloquinoline Quinone Safety
PQQ (pyrroloquinoline quinone) has a good safety profile. It is naturally found in a variety of foods, and the daily intake of human beings through diet is about 0.1-1 mg/day. It can also be detected in breast milk and human tissues, and has natural physiological compatibility.
Animal studies have shown that the median lethal dose (LD50) for acute toxicity is high, and the safe dose at which no adverse effects were observed in subchronic studies is up to 400 mg per kilogram of body weight per day; no bone marrow toxicity was also found in mouse in vivo studies at doses up to 2000 mg per kilogram of body weight per day.
Importantly, in a 4-week human clinical trial, subjects supplemented with 20 or 60 mg of PQQ daily (far exceeding the usual intake) without experiencing adverse reactions, and all clinical indicators remained normal. These data collectively demonstrate that PQQ has a good oral safety profile at doses far exceeding the usual intake and common supplement usage levels.
Reference: https://journals.lww.com/nrronline/fulltext/2025/01000/pyrroloquinoline_quinone__a_potential.5.aspx.
What is PQQ used for?
Currently, common PQQ supplement products on the market mainly target brain health, sleep aid, energy replenishment, oral beauty, and fertility assistance, and are often used in combination with various raw materials such as MNM, coenzyme Q10 and ginkgo leaf extract.
Furthermore, it demonstrates significant potential in the field of metabolic health: it is suitable for the prevention and improvement of obesity-related metabolic complications such as obesity, non-alcoholic fatty liver disease, type 2 diabetes, and chronic kidney disease. It can also be used in combination with atorvastatin to enhance its lipid-lowering and anti-inflammatory effects. Its main functions include reducing visceral and liver fat accumulation, inhibiting lipogenesis, promoting mitochondrial biosynthesis, regulating gut microbiota balance, and exerting antioxidant and anti-inflammatory effects, thereby improving dyslipidemia and insulin resistance.
Reference: https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2023.1200025/full
Kintainutri® -Your Trusted PQQ powder partner. If you need to Pyrroloquinoline Quinone Powder, please feel free to contact us at any time.
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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