Pharm Ingredients
Psoralea Corylifolia Seed Extract Psoralen Powder
Kintainutri® Factory Supply Psoralea Corylifolia Seed Extract Psoralen Powder
Kintainutri® has many years of experience providing cosmetic-grade ingredients, we
extracted 98% Bakuchiol, 5%–98% Psoralen, 98% Isopsoralen, and 1%–98% Psoralenoside from psoralea corylifolia seed using safe and conventional ethanol solvent. Best-selling specifications of product information is as follows:
extracted 98% Bakuchiol, 5%–98% Psoralen, 98% Isopsoralen, and 1%–98% Psoralenoside from psoralea corylifolia seed using safe and conventional ethanol solvent. Best-selling specifications of product information is as follows:
Psoralen is the most important active ingredient in psoralea corylifolia. It has photosensitizing, estrogen-like effects, and anti-inflammatory, anti-immunosuppressive, melanin-increasing, and anti-tumor activities. It can bind to ultraviolet light (UVA), induce DNA cross-linking, and inhibit abnormal cell proliferation. It is often used to treat skin diseases such as vitiligo and psoriasis.
Psoralea Corylifolia Seed Extract Psoralen Powder Specification
| Item | Specifications | Results |
|---|---|---|
| Assay | Psoralen≥98% | 98.18% |
| Appearance | White Powder | Conforms |
| Odor | Characteristic | Conforms |
| Mesh Size | 100% pass 80 mesh | Conforms |
| Loss on Drying | ≤5.0 ppm | Conforms |
| Identification | Positive | Conforms |
| Residue Analysis | ||
| Pb | ≤1.0 ppm | Conforms |
| Hg | ≤0.1 ppm | Conforms |
| Cd | ≤1.0 ppm | Conforms |
| As | ≤1.0 ppm | Conforms |
| Solvents Residue | ≤1000 ppm | Conforms |
| Microbiological Tests | ||
| Total plate count(cfu/g) | ≤1000 cfu/g | Conforms |
| Yeast & Mold count(cfu/g) | ≤100 cfu/g | Conforms |
| E.coli | Negative | Conforms |
| Salmonella | Negative | Conforms |
| Staphylococcus | Negative | Conforms |
| Conclusion | Confirm to Specification and Standards. | |
Psoralea Corylifolia Seed Extract Psoralen Powder production Process
Psoralea Corylifolia Seed Extract Psoralen Powder Benefits
Psoralen powder benefits for skin
Methoxsalen possesses core pharmacological effects of anti-inflammation and anti-oxidation. As a melanocortin 1 receptor (MC1R) antagonist, it can inhibit the expression of inflammatory mediators (such as TNF-α and IL-6) and alleviate the symptoms of inflammatory skin diseases such as atopic dermatitis.
It also has photosensitizing properties and is often used in combination with ultraviolet A light to treat skin diseases such as psoriasis and eczema. In addition, psoralen can promote the survival of keratinocytes but inhibit melanin production, which helps regulate skin pigment metabolism.
Psoralen powder benefits for osteoporosis
Studies have shown that psoralen can upregulate the expression of osteoblast-specific marker genes and enhance ALP activity by activating multiple signaling pathways such as BMP and NF-κB-MAPK, thereby promoting osteoblast differentiation and proliferation.
It can also inhibit the activation of AKT and AP-1 pathways to reduce osteoclast differentiation and decrease bone resorption and bone turnover rates in osteoporosis patients. At the same time, it can activate osteoblasts and osteoclasts to promote fracture healing and significantly improve bone mass indicators in ovariectomized osteoporosis model animals, demonstrating good anti-osteoporosis potential.
Psoralen powder benefits for the treatment of skin diseases
Psoralen powder has significant therapeutic effects on refractory skin diseases such as vitiligo and psoriasis. Its ointment, when used alone for topical application, is effective in treating small, round white patches of vitiligo. It can be combined with ultraviolet A to form PUVA therapy, which can effectively improve the symptoms of moderate to severe psoriasis, whether taken orally or used in baths.
It can also downregulate the expression of inflammatory factors and related microRNAs in psoriasis models, reduce the skin's responsiveness to Toll-like receptor activation, and alleviate skin inflammation.
It can also downregulate the expression of inflammatory factors and related microRNAs in psoriasis models, reduce the skin's responsiveness to Toll-like receptor activation, and alleviate skin inflammation.
Psoralea Corylifolia Seed Extract Psoralen Powder Uses
Psoralen powder for medication
Psoralen powder has a wide range of clinical applications and can be made into psoralen preparations, such as psoralen injection, psoralen ointment, compound psoralen granules, psoralen gel, and psoralen tablets. It is mainly used to treat uterine bleeding, psoriasis, vitiligo, and other diseases.
Psoralea Corylifolia Seed Extract Psoralen Powder Side Effects
Long-term or repeated use of psoralen significantly increases the risk of hepatotoxicity. The drug tends to accumulate in the body, leading to slower clearance and prolonged duration of action.
Animal studies have shown that repeated administration of high doses resulted in persistently high blood drug concentrations; in vitro experiments have also confirmed that long-term exposure to low concentrations inhibits hepatocyte viability and interferes with the cell cycle. Therefore, long-term or high-dose use should raise concerns about its cumulative liver damage.
Animal studies have shown that repeated administration of high doses resulted in persistently high blood drug concentrations; in vitro experiments have also confirmed that long-term exposure to low concentrations inhibits hepatocyte viability and interferes with the cell cycle. Therefore, long-term or high-dose use should raise concerns about its cumulative liver damage.
Where Can I buy psoralen Powder?
●Kintainutri® offer high-quality psoralen powder. Leveraging our core advantages of flexible supply and efficient logistics, we support minimum order quantities as low as 1 kg and provide packaging options of 1 kg/bag or 25 kg/drum.
●Psoralea corylifolia fruit extract will be shipped via FedEx and are expected to arrive in 5-9 business days. In terms of products, we offer a variety of psoralea corylifolia seed extract powders with concentrations ranging from 1% to 98%, and can also customize production to meet your specific needs.
●Psoralea corylifolia fruit extract will be shipped via FedEx and are expected to arrive in 5-9 business days. In terms of products, we offer a variety of psoralea corylifolia seed extract powders with concentrations ranging from 1% to 98%, and can also customize production to meet your specific needs.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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