Pharm Ingredients

Resveratrol Powder

Product name: Resveratrol Powder
Other Name: Trans-Resveratrol, 3,4',5-Trihydroxystilbene
Source: Grape, Polygonum cuspidatum/Fermentation Synthesis/Chemical synthesis
Specifications: 5%,10%,50%,98% natural resveratrol, 99% fermented resveratrol and 99% synthesized resveratrol
Appearance: White Needle Crystal Powder
CAS No: 501-36-0
Test Method: HPLC
MOQ: 1KG
Delivery Time: Delivery within one day from warehouse
Sample: Free sample available
Production Capacity: 2000KG/month
Certs: GMP, ISO9001, ISO22000, HACCP, KOSHER, HALAL
Content: Natural, Non-additive, Non-GMO, Treat by Heat Only
Categories: Herbal Extract, Cosmetic Ingredients, Healthcare Supplement, Pharm Ingredients
Payment: Multiple terms acceptable like T/T, Alipay, Paypal
Company Advantage: Kintainutri® mainly focuses on the production of high content plant extracts and pharmaceutical intermediates all the year round.
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product details

Resveratrol Powder Manufacturers

Leveraging rigorous quality control and consistent product quality, Kintainutri® supplies high-purity resveratrol powder in concentrations ranging from 5% to 99%. Resveratrol is a natural polyphenolic phytoalexin synthesized by plants in response to environmental stress and is commonly found in grape skins, blueberries, and Polygonum cuspidatum (Japanese knotweed).

Structurally, resveratrol consists of two phenolic rings linked by an ethylene bridge and exists predominantly in the trans isomeric form, which exhibits excellent stability. Owing to its potent antioxidant properties, resveratrol effectively scavenges free radicals and exhibits a wide range of biological activities, including cardioprotective, neuroprotective, and anti-inflammatory effects, as well as support for healthy aging.

Product Name	Plant Source	Specifications	Test Method
Resveratrol Powder	Grape / Polygonum cuspidatum	5%	HPLC
		10%
		50%
	Fermentation Synthesis	98%
	Chemical Synthesis	99%
	Chemical Synthesis	99%

what is resveratrol?

Commercially available resveratrol raw materials are predominantly supplied in the form of trans-resveratrol. The trans isomer is the naturally predominant form of resveratrol and the configuration responsible for its biological activity. Compared with the cis isomer, it exhibits greater thermodynamic stability and higher bioavailability. Consequently, industry standards for content determination, product specifications, and efficacy evaluation are based on trans-resveratrol. Kintainutri® supplies high-purity trans-resveratrol powder suitable for a wide range of applications, including dietary supplements and cosmetic formulations, providing reliable functional ingredient solutions for customers worldwide.

cGMP KINTAI factory supply
Best natural source of Resveratrol extract powder

resveratrol Chemical & Physical Properties

CAS Number	501-36-0	Density	1.359±0.06 g/cm3 (Predicted)
Molecular Formula	C14H12O3	Molecular Weight	228.24
Melting Point	253-255 ℃	Boiling Point	449.1±14.0 ℃ (Predicted)
Solubleness	Soluble in DMSO (up to 25mg/ml) or ethanol (up to 20mg/ml).	Test Method	HPLC

Resveratrol Powder COA

How To Make Resveratrol Powder?

resveratrol powder production process flow chart

Resveratrol Powder Benefits

resveratrol benefits for women

Resveratrol is a natural polyphenolic phytoalexin with a structure resembling the synthetic estrogen diethylstilbestrol; it can bind to estrogen receptors and exhibit activity similar to that of selective estrogen receptor modulators (SERMs). Studies indicate that resveratrol supplementation can significantly alleviate chronic musculoskeletal pain, an effect associated with its anti-inflammatory and antioxidant properties, as well as its ability to improve tissue blood perfusion.

Additionally, it lowers levels of the bone resorption marker CTX, suggesting a potential protective role in bone health. It also shows potential for improving cognitive function, mood, metabolic parameters, and menopausal symptoms. Resveratrol powder is suitable for the development of formulations targeting women's health and bone health.

source: https://pmc.ncbi.nlm.nih.gov/articles/PMC12325339/

resveratrol benefits for men

Resveratrol benefits fertility by enhancing sperm motility and quality through the improvement of energy metabolism and mitochondrial function in testicular cells. It mitigates reproductive tract inflammation by inhibiting the NF-κB pathway and COX/LOX enzyme activity, thereby reducing the release of pro-inflammatory cytokines. Additionally, it protects sperm DNA integrity by activating the Nrf2 antioxidant pathway, scavenging free radicals, and lowering lipid peroxidation; it also modulates estrogen receptor activity, playing a role in the hormonal regulation of testicular development and spermatogenesis.

Clinical studies show that daily supplementation with 150 mg of resveratrol combined with vitamins leads to a significant increase in sperm concentration and total sperm count after 3–6 months. Animal studies have further confirmed that resveratrol can alleviate testicular damage caused by toxins such as nicotine and cisplatin. In the fields of male reproductive health and antioxidants, Kintainutri® high-purity resveratrol powder serves as a key functional ingredient for the development of related formulations.

resveratrol benefits for skin

Resveratrol exerts protective and reparative effects on the skin care. Regarding protection against photoaging, resveratrol inhibits the activation of UVB-induced MAPK and NF-κB signaling pathways, thereby reducing the expression of matrix metalloproteinase-1 (MMP-1), minimizing collagen degradation, and simultaneously upregulating TGF-β and type I procollagen levels to maintain the skin's elastic structure.

Its antioxidant activity is demonstrated by activating endogenous antioxidant enzymes, such as SOD and GSH-Px, scavenging UVA-induced reactive oxygen species (ROS), and reducing lipid peroxidation damage. In terms of its anti-inflammatory effects, resveratrol inhibits the release of pro-inflammatory mediators, including COX-2, IL-6, and TNF-α, thereby alleviating UV-induced skin edema and inflammatory responses.

Furthermore, it promotes angiogenesis, accelerates wound healing and tissue regeneration, and reduces scar formation. It also inhibits melanogenesis, reduces hyperpigmentation, improves the appearance of enlarged pores, and enhances overall skin tone evenness. For anti-aging and skin-repair cosmetic formulations, Kintainutri® resveratrol powder provides a reliable, multi-target active ingredient.

source: https://pmc.ncbi.nlm.nih.gov/articles/PMC9326919/

resveratrol anti aging

Resveratrol delays the aging process through multi-target pathways: it inhibits oxidative stress, scavenges free radicals, and reduces oxidative damage to lipids and DNA; it suppresses inflammatory responses and lowers the secretion of pro-inflammatory cytokines; it improves mitochondrial function, promoting mitochondrial biogenesis and the maintenance of function; and it regulates apoptosis, protecting neurons and muscle cells.

Resveratrol can improve cognitive function, physical performance, and cardiovascular health, while offering protective effects against age-related conditions such as neurodegenerative diseases, sarcopenia, and osteoporosis. The resveratrol powder supplied by Kintainutri® holds potential for the formulation of anti-aging and age-related health products.

source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8289612/

benefits of resveratrol and weight loss

Resveratrol mimics the metabolic effects of caloric restriction by activating AMPK and upregulating the protein expression of SIRT1 and PGC-1α, thereby enhancing mitochondrial fatty acid oxidation capacity in skeletal muscle. Studies have shown that daily supplementation with 150 mg of trans-resveratrol in obese men significantly reduces resting and sleep metabolic rates, indicating improved metabolic efficiency. It also decreases liver fat content, plasma triglyceride and blood glucose levels, inflammatory markers, and systolic blood pressure by approximately 5 mmHg.

These changes occur without weight loss, demonstrating that resveratrol can improve metabolic health independently of body weight reduction and holds unique value for weight management formulations; Kintainutri®’s resveratrol powder meets the raw material requirements for products focused on metabolic support, improved insulin sensitivity, and liver fat management.

What Is Resveratrol Powder Used For？

resveratrol powder supplement

Resveratrol is a naturally occurring polyphenol found in sources such as grapes and Polygonum cuspidatum; it has garnered significant attention in the dietary supplement sector due to its antioxidant, anti-inflammatory, and metabolic-regulating properties. Trans resveratrol supplements offer potential benefits for metabolic health, including improved insulin sensitivity, reduced blood glucose and triglyceride levels, and assistance in managing systolic blood pressure. Furthermore, resveratrol exhibits diverse biological activities, such as cardiovascular protection, neuroprotection, and anti-aging effects.

When formulating products, it is advisable to determine the appropriate dosage based on the metabolic status of the target population and to consider combining resveratrol with complementary ingredients, such as vitamins or piperine, to enhance bioavailability and achieve synergistic effects. Kintainutri® high-purity resveratrol powder is suitable for use in the formulation of dietary resveratrol supplements and trans-resveratrol tablets.

resveratrol skin cream

As a natural polyphenol, resveratrol exhibits multi-target activity in skincare formulations. Topical preparations containing resveratrol can enhance skin elasticity, diminish wrinkles, and reduce pigmentation, thereby improving uneven skin tone. Furthermore, resveratrol mitigates oxidative skin damage by scavenging free radicals through the activation of the Nrf2/HO-1 antioxidant pathway. The application of advanced delivery systems, such as resveratrol face cream, nanoemulsions, liposomes, and hydrogels, further enhances its transdermal penetration and stability, making it a reliable functional ingredient for anti-aging, skin-brightening, and photodamage-repair skincare formulations.

Resveratrol Powder Dosage

Existing clinical studies have investigated a wide range of resveratrol dosages, from 8 mg to 2 g per day, with generally favorable safety profiles. For metabolic health, daily supplementation with 150 mg of trans-resveratrol has been shown to improve metabolic markers in obese men, including reductions in blood glucose, triglyceride levels, inflammatory markers, and systolic blood pressure. In older adults, high daily doses of 1–2 g were well-tolerated and associated with improved insulin sensitivity.

Clinical studies on male reproductive health observed significant increases in sperm concentration and total sperm count following 3–6 months of daily supplementation with 150 mg of resveratrol combined with vitamins. Among patients with cardiovascular disease, a one-year study demonstrated that resveratrol-containing formulations (administered at a low dose for the first six months and a double dose for the subsequent six months) were well-tolerated. Effective dosages vary depending on the indication, target population, and formulation.

Current evidence suggests that a daily intake of 150–500 mg offers a favorable risk-benefit profile for metabolic and reproductive health; however, larger, long-term clinical studies are required to confirm the optimal dosage for specific populations, such as the elderly and individuals with chronic diseases.

Resveratrol Powder Side Effects

Resveratrol is not entirely free of risk. High doses (exceeding 2 g daily) can cause gastrointestinal discomfort, such as diarrhea, nausea, and anal itching. In clinical trials, a daily dose of 5 g induced nephrotoxicity and electrolyte imbalances in patients with multiple myeloma, and even resulted in fatalities. High doses of resveratrol can also inhibit drug-metabolizing enzymes such as CYP3A4 and CYP2C9, thereby affecting the efficacy of co-administered medications (e.g., warfarin and statins); additionally, it interferes with thyroid function, manifesting as goiter and inhibition of iodine uptake. Long-term supplementation with high doses of resveratrol may increase cardiovascular risk markers, including oxidized LDL and E-selectin, and may also lead to elevated liver enzyme levels and leukopenia.

Resveratrol exhibits dose-dependent effects. While low doses (150–500 mg/day) are generally well tolerated, high doses may shift its activity from antioxidant to pro-oxidant, potentially inducing DNA damage and apoptosis. Therefore, daily dosages should be carefully controlled within established safety limits during formulation development.

Where Can i Buy Resveratrol Powder?

Kintainutri® offers resveratrol powder in specifications ranging from 5% to 99%, providing a reliable source of functional ingredients for diverse product development. Backed by rigorous quality control systems and a stable supply chain, we ensure high product purity and batch-to-batch consistency, making our ingredients suitable for skincare formulations, such as creams and serums, as well as dietary supplements.

We also provide customized specifications and comprehensive compliance documentation, helping global clients efficiently accelerate the journey from product concept to market launch. Please contact the Kintainutri® team for samples, COAs, or technical consultation.

Reference:
[1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC12325339/
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC11826399/
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9326919/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC8289612/
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC3880862/
[6]: https://www.sciencedirect.com/science/article/abs/pii/S0531556514001764
[7]: https://pmc.ncbi.nlm.nih.gov/articles/PMC7139620/
[8]: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00413/

FAQ

How to take resveratrol powder？

The method of administering resveratrol powder depends on the product's intended use and target demographic. When used as a dietary supplement, the powder is typically mixed with warm water, fruit juice, or a protein shake; however, due to its low water solubility, thorough stirring is required to ensure even dispersion. It is recommended to take it with or after a meal, as its fat-soluble nature facilitates better absorption in the presence of dietary fats; a typical single dose ranges from 100 to 500 mg, though specific amounts should be determined based on product specifications or formulation design. For topical applications, resveratrol powder can be dissolved in oil-based or alcohol-based solvents and incorporated into creams, serums, or facial masks to provide antioxidant skincare benefits. It should be noted that resveratrol has low oral bioavailability; however, absorption efficiency can be significantly enhanced by combining it with ingredients such as piperine or quercetin, or by utilizing nano-delivery technologies. Professional guidance is recommended to determine the specific usage and dosage before use.
What foods contain resveratrol？

Natural foods rich in resveratrol primarily include grapes (especially the skins of purple-red varieties), red wine, peanuts, and certain berries; among these, grapes and red wine are the most representative sources, as resveratrol is released from grape skins into the wine during fermentation. Berries such as blueberries, cranberries, and mulberries, as well as pistachios, also contain measurable amounts of resveratrol. However, within the extract industry, Polygonum cuspidatum serves as the primary industrial raw material for resveratrol production; the resveratrol content in its dried rhizomes is far higher than that of common food sources like grapes (reaching 1–4 mg/g), and the extraction process is well-established, enabling the stable production of high-purity (≥98%) products—offering significant economic value and industrial advantages.

Can resveratrol help you lose weight？

It may play a role in ameliorating central obesity; its underlying mechanisms involve the activation of pathways such as AMPK and SIRT-1, the inhibition of adipogenesis, and the improvement of energy metabolism, with some early studies also observing effects mimicking caloric restriction. Overall, existing evidence indicates that resveratrol should not be viewed as a direct weight-loss supplement; its primary value lies in improving metabolic health rather than directly reducing body weight.